| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSPPYP00000017062 | HSP90AB1 | ENSPPYP00000017062 | ENSPPYP00000018631 | annotation not available | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.983 |
| ENSPPYP00000017062 | PPID | ENSPPYP00000017062 | ENSPPYP00000016942 | annotation not available | Peptidylprolyl isomerase D. | 0.909 |
| ENSPPYP00000017062 | PTGES3 | ENSPPYP00000017062 | ENSPPYP00000005319 | annotation not available | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.942 |
| ENSPPYP00000017062 | STIP1 | ENSPPYP00000017062 | ENSPPYP00000003602 | annotation not available | STIP1 isoform 2. | 0.951 |
| HSP90AA1 | HSP90AB1 | ENSPPYP00000006994 | ENSPPYP00000018631 | HSP90AA1 isoform 6. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.983 |
| HSP90AA1 | PPID | ENSPPYP00000006994 | ENSPPYP00000016942 | HSP90AA1 isoform 6. | Peptidylprolyl isomerase D. | 0.909 |
| HSP90AA1 | PTGES3 | ENSPPYP00000006994 | ENSPPYP00000005319 | HSP90AA1 isoform 6. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.942 |
| HSP90AA1 | STIP1 | ENSPPYP00000006994 | ENSPPYP00000003602 | HSP90AA1 isoform 6. | STIP1 isoform 2. | 0.951 |
| HSP90AB1 | ENSPPYP00000017062 | ENSPPYP00000018631 | ENSPPYP00000017062 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | annotation not available | 0.983 |
| HSP90AB1 | HSP90AA1 | ENSPPYP00000018631 | ENSPPYP00000006994 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | HSP90AA1 isoform 6. | 0.983 |
| HSP90AB1 | PPID | ENSPPYP00000018631 | ENSPPYP00000016942 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Peptidylprolyl isomerase D. | 0.885 |
| HSP90AB1 | PTGES3 | ENSPPYP00000018631 | ENSPPYP00000005319 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.927 |
| HSP90AB1 | STIP1 | ENSPPYP00000018631 | ENSPPYP00000003602 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | STIP1 isoform 2. | 0.983 |
| PPID | ENSPPYP00000017062 | ENSPPYP00000016942 | ENSPPYP00000017062 | Peptidylprolyl isomerase D. | annotation not available | 0.909 |
| PPID | HSP90AA1 | ENSPPYP00000016942 | ENSPPYP00000006994 | Peptidylprolyl isomerase D. | HSP90AA1 isoform 6. | 0.909 |
| PPID | HSP90AB1 | ENSPPYP00000016942 | ENSPPYP00000018631 | Peptidylprolyl isomerase D. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.885 |
| PPID | PPIF | ENSPPYP00000016942 | ENSPPYP00000002675 | Peptidylprolyl isomerase D. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.934 |
| PPID | PTGES3 | ENSPPYP00000016942 | ENSPPYP00000005319 | Peptidylprolyl isomerase D. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.927 |
| PPID | SLC25A31 | ENSPPYP00000016942 | ENSPPYP00000016818 | Peptidylprolyl isomerase D. | SLC25A31 isoform 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.929 |
| PPID | SLC25A4 | ENSPPYP00000016942 | ENSPPYP00000017028 | Peptidylprolyl isomerase D. | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.913 |
