AADAT protein (Pongo abelii) - STRING interaction network

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADAT	AFMID	ENSPPYP00000016979	ENSPPYP00000009753	Aminoadipate aminotransferase.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.932
AADAT	ALDH7A1	ENSPPYP00000016979	ENSPPYP00000023896	Aminoadipate aminotransferase.	ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family.	0.923
AADAT	BCAT1	ENSPPYP00000016979	ENSPPYP00000004984	Aminoadipate aminotransferase.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.757
AADAT	BCAT2	ENSPPYP00000016979	ENSPPYP00000011426	Aminoadipate aminotransferase.	Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity).	0.757
AADAT	CR201_G0027561	ENSPPYP00000016979	ENSPPYP00000022040	Aminoadipate aminotransferase.	KYAT1 isoform 2.	0.962
AADAT	DHTKD1	ENSPPYP00000016979	ENSPPYP00000003298	Aminoadipate aminotransferase.	Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).	0.938
AADAT	KMO	ENSPPYP00000016979	ENSPPYP00000000068	Aminoadipate aminotransferase.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.956
AADAT	KYAT3	ENSPPYP00000016979	ENSPPYP00000001362	Aminoadipate aminotransferase.	Kynurenine aminotransferase 3.	0.942
AADAT	KYNU	ENSPPYP00000016979	ENSPPYP00000014317	Aminoadipate aminotransferase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.952
AADAT	SHE	ENSPPYP00000016979	ENSPPYP00000000908	Aminoadipate aminotransferase.	Src homology 2 domain containing E.	0.727
AFMID	AADAT	ENSPPYP00000009753	ENSPPYP00000016979	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Aminoadipate aminotransferase.	0.932
AFMID	CR201_G0027561	ENSPPYP00000009753	ENSPPYP00000022040	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	KYAT1 isoform 2.	0.936
AFMID	KMO	ENSPPYP00000009753	ENSPPYP00000000068	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.970
AFMID	KYAT3	ENSPPYP00000009753	ENSPPYP00000001362	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynurenine aminotransferase 3.	0.929
AFMID	KYNU	ENSPPYP00000009753	ENSPPYP00000014317	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.978
ALDH7A1	AADAT	ENSPPYP00000023896	ENSPPYP00000016979	ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family.	Aminoadipate aminotransferase.	0.923
ALDH7A1	DHTKD1	ENSPPYP00000023896	ENSPPYP00000003298	ALDH7A1 isoform 1; Belongs to the aldehyde dehydrogenase family.	Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).	0.410
BCAT1	AADAT	ENSPPYP00000004984	ENSPPYP00000016979	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Aminoadipate aminotransferase.	0.757
BCAT1	BCAT2	ENSPPYP00000004984	ENSPPYP00000011426	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity).	0.901
BCAT2	AADAT	ENSPPYP00000011426	ENSPPYP00000016979	Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity).	Aminoadipate aminotransferase.	0.757