| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APAF1 | BIRC2 | ENSPPYP00000005543 | ENSPPYP00000004356 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 2. | 0.736 |
| APAF1 | CASP3 | ENSPPYP00000005543 | ENSPPYP00000017020 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.994 |
| APAF1 | CASP8 | ENSPPYP00000005543 | ENSPPYP00000014605 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP8 isoform 1; Belongs to the peptidase C14A family. | 0.817 |
| APAF1 | CASP9 | ENSPPYP00000005543 | ENSPPYP00000002138 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.999 |
| APAF1 | CYCS | ENSPPYP00000005543 | ENSPPYP00000019862 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.998 |
| APAF1 | XIAP | ENSPPYP00000005543 | ENSPPYP00000023167 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | XIAP isoform 2. | 0.943 |
| BIRC2 | APAF1 | ENSPPYP00000004356 | ENSPPYP00000005543 | Baculoviral IAP repeat containing 2. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.736 |
| BIRC2 | CASP3 | ENSPPYP00000004356 | ENSPPYP00000017020 | Baculoviral IAP repeat containing 2. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.996 |
| BIRC2 | CASP8 | ENSPPYP00000004356 | ENSPPYP00000014605 | Baculoviral IAP repeat containing 2. | CASP8 isoform 1; Belongs to the peptidase C14A family. | 0.908 |
| BIRC2 | CASP9 | ENSPPYP00000004356 | ENSPPYP00000002138 | Baculoviral IAP repeat containing 2. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.996 |
| BIRC2 | CYCS | ENSPPYP00000004356 | ENSPPYP00000019862 | Baculoviral IAP repeat containing 2. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.491 |
| BIRC2 | XIAP | ENSPPYP00000004356 | ENSPPYP00000023167 | Baculoviral IAP repeat containing 2. | XIAP isoform 2. | 0.998 |
| CASP3 | APAF1 | ENSPPYP00000017020 | ENSPPYP00000005543 | CASP3 isoform 1; Belongs to the peptidase C14A family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.994 |
| CASP3 | BIRC2 | ENSPPYP00000017020 | ENSPPYP00000004356 | CASP3 isoform 1; Belongs to the peptidase C14A family. | Baculoviral IAP repeat containing 2. | 0.996 |
| CASP3 | CASP8 | ENSPPYP00000017020 | ENSPPYP00000014605 | CASP3 isoform 1; Belongs to the peptidase C14A family. | CASP8 isoform 1; Belongs to the peptidase C14A family. | 0.994 |
| CASP3 | CASP9 | ENSPPYP00000017020 | ENSPPYP00000002138 | CASP3 isoform 1; Belongs to the peptidase C14A family. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.997 |
| CASP3 | CDKN1A | ENSPPYP00000017020 | ENSPPYP00000018511 | CASP3 isoform 1; Belongs to the peptidase C14A family. | Cyclin dependent kinase inhibitor 1A. | 0.995 |
| CASP3 | CYCS | ENSPPYP00000017020 | ENSPPYP00000019862 | CASP3 isoform 1; Belongs to the peptidase C14A family. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.993 |
| CASP3 | DFFA | ENSPPYP00000017020 | ENSPPYP00000002201 | CASP3 isoform 1; Belongs to the peptidase C14A family. | DNA fragmentation factor subunit alpha. | 0.997 |
| CASP3 | MAPT | ENSPPYP00000017020 | ENSPPYP00000009325 | CASP3 isoform 1; Belongs to the peptidase C14A family. | Microtubule-associated protein. | 0.992 |
