| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1 | ENSPPYP00000017058 | ENSPPYP00000007036 | ENSPPYP00000017058 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | annotation not available | 0.689 |
| AKT1 | FKBP4 | ENSPPYP00000007036 | ENSPPYP00000004732 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Peptidylprolyl isomerase. | 0.403 |
| AKT1 | FKBP5 | ENSPPYP00000007036 | ENSPPYP00000018489 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity). | 0.804 |
| AKT1 | HSPA4 | ENSPPYP00000007036 | ENSPPYP00000017643 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.502 |
| AKT1 | NR3C1 | ENSPPYP00000007036 | ENSPPYP00000017784 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.454 |
| ENSPPYP00000017058 | AKT1 | ENSPPYP00000017058 | ENSPPYP00000007036 | annotation not available | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.689 |
| ENSPPYP00000017058 | FKBP4 | ENSPPYP00000017058 | ENSPPYP00000004732 | annotation not available | Peptidylprolyl isomerase. | 0.753 |
| ENSPPYP00000017058 | FKBP5 | ENSPPYP00000017058 | ENSPPYP00000018489 | annotation not available | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity). | 0.712 |
| ENSPPYP00000017058 | HSF1 | ENSPPYP00000017058 | ENSPPYP00000021274 | annotation not available | HSF1 isoform 2. | 0.718 |
| ENSPPYP00000017058 | HSPA4 | ENSPPYP00000017058 | ENSPPYP00000017643 | annotation not available | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.717 |
| ENSPPYP00000017058 | NR3C1 | ENSPPYP00000017058 | ENSPPYP00000017784 | annotation not available | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.688 |
| ENSPPYP00000017058 | PPID | ENSPPYP00000017058 | ENSPPYP00000016942 | annotation not available | Peptidylprolyl isomerase D. | 0.747 |
| ENSPPYP00000017058 | PTGES3 | ENSPPYP00000017058 | ENSPPYP00000005319 | annotation not available | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.811 |
| ENSPPYP00000017058 | STIP1 | ENSPPYP00000017058 | ENSPPYP00000003602 | annotation not available | STIP1 isoform 2. | 0.836 |
| ENSPPYP00000017058 | SUGT1 | ENSPPYP00000017058 | ENSPPYP00000006144 | annotation not available | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. | 0.751 |
| FKBP4 | AKT1 | ENSPPYP00000004732 | ENSPPYP00000007036 | Peptidylprolyl isomerase. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.403 |
| FKBP4 | ENSPPYP00000017058 | ENSPPYP00000004732 | ENSPPYP00000017058 | Peptidylprolyl isomerase. | annotation not available | 0.753 |
| FKBP4 | FKBP5 | ENSPPYP00000004732 | ENSPPYP00000018489 | Peptidylprolyl isomerase. | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity). | 0.995 |
| FKBP4 | HSF1 | ENSPPYP00000004732 | ENSPPYP00000021274 | Peptidylprolyl isomerase. | HSF1 isoform 2. | 0.726 |
| FKBP4 | HSPA4 | ENSPPYP00000004732 | ENSPPYP00000017643 | Peptidylprolyl isomerase. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.672 |
