GUCY1A1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENPP1	ENPP3	ENSPPYP00000019048	ENSPPYP00000019047	ENPP1 isoform 1.	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	0.920
ENPP1	ENSPPYP00000006126	ENSPPYP00000019048	ENSPPYP00000006126	ENPP1 isoform 1.	annotation not available	0.910
ENPP1	GCH1	ENSPPYP00000019048	ENSPPYP00000006627	ENPP1 isoform 1.	GTP cyclohydrolase 1.	0.800
ENPP1	GUCY1A1	ENSPPYP00000019048	ENSPPYP00000017082	ENPP1 isoform 1.	GUCY1A3 isoform 10; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.900
ENPP1	GUCY1B1	ENSPPYP00000019048	ENSPPYP00000016926	ENPP1 isoform 1.	GUCY1B3 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.910
ENPP1	NUDT2	ENSPPYP00000019048	ENSPPYP00000021430	ENPP1 isoform 1.	Nudix hydrolase 2.	0.915
ENPP1	PDE9A	ENSPPYP00000019048	ENSPPYP00000012789	ENPP1 isoform 1.	Phosphodiesterase.	0.679
ENPP3	ENPP1	ENSPPYP00000019047	ENSPPYP00000019048	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	ENPP1 isoform 1.	0.920
ENPP3	ENSPPYP00000006126	ENSPPYP00000019047	ENSPPYP00000006126	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	annotation not available	0.910
ENPP3	GCH1	ENSPPYP00000019047	ENSPPYP00000006627	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	GTP cyclohydrolase 1.	0.800
ENPP3	GUCY1A1	ENSPPYP00000019047	ENSPPYP00000017082	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	GUCY1A3 isoform 10; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.900
ENPP3	GUCY1B1	ENSPPYP00000019047	ENSPPYP00000016926	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	GUCY1B3 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.910
ENPP3	NUDT2	ENSPPYP00000019047	ENSPPYP00000021430	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	Nudix hydrolase 2.	0.912
ENPP3	PDE9A	ENSPPYP00000019047	ENSPPYP00000012789	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	Phosphodiesterase.	0.679
ENSPPYP00000006126	ENPP1	ENSPPYP00000006126	ENSPPYP00000019048	annotation not available	ENPP1 isoform 1.	0.910
ENSPPYP00000006126	ENPP3	ENSPPYP00000006126	ENSPPYP00000019047	annotation not available	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...]	0.910
ENSPPYP00000006126	GCH1	ENSPPYP00000006126	ENSPPYP00000006627	annotation not available	GTP cyclohydrolase 1.	0.809
ENSPPYP00000006126	GUCY1A1	ENSPPYP00000006126	ENSPPYP00000017082	annotation not available	GUCY1A3 isoform 10; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.958
ENSPPYP00000006126	NOS1	ENSPPYP00000006126	ENSPPYP00000005707	annotation not available	NOS1 isoform 2.	0.907
ENSPPYP00000006126	NUDT2	ENSPPYP00000006126	ENSPPYP00000021430	annotation not available	Nudix hydrolase 2.	0.900