| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACD | DKC1 | ENSPPYP00000008431 | ENSPPYP00000023387 | ACD shelterin complex subunit and telomerase recruitment factor. | DKC1 isoform 2. | 0.807 |
| ACD | GAR1 | ENSPPYP00000008431 | ENSPPYP00000016749 | ACD shelterin complex subunit and telomerase recruitment factor. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.736 |
| ACD | NHP2 | ENSPPYP00000008431 | ENSPPYP00000018020 | ACD shelterin complex subunit and telomerase recruitment factor. | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.807 |
| ACD | NOP10 | ENSPPYP00000008431 | ENSPPYP00000007153 | ACD shelterin complex subunit and telomerase recruitment factor. | NOP10 ribonucleoprotein. | 0.808 |
| ACD | POT1 | ENSPPYP00000008431 | ENSPPYP00000020151 | ACD shelterin complex subunit and telomerase recruitment factor. | POT1 isoform 2. | 0.998 |
| ACD | TERT | ENSPPYP00000008431 | ENSPPYP00000017108 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.923 |
| ACD | WRAP53 | ENSPPYP00000008431 | ENSPPYP00000009938 | ACD shelterin complex subunit and telomerase recruitment factor. | WRAP53 isoform 2. | 0.730 |
| DKC1 | ACD | ENSPPYP00000023387 | ENSPPYP00000008431 | DKC1 isoform 2. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.807 |
| DKC1 | GAR1 | ENSPPYP00000023387 | ENSPPYP00000016749 | DKC1 isoform 2. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.999 |
| DKC1 | NHP2 | ENSPPYP00000023387 | ENSPPYP00000018020 | DKC1 isoform 2. | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.999 |
| DKC1 | NOP10 | ENSPPYP00000023387 | ENSPPYP00000007153 | DKC1 isoform 2. | NOP10 ribonucleoprotein. | 0.999 |
| DKC1 | POT1 | ENSPPYP00000023387 | ENSPPYP00000020151 | DKC1 isoform 2. | POT1 isoform 2. | 0.656 |
| DKC1 | SMG6 | ENSPPYP00000023387 | ENSPPYP00000008776 | DKC1 isoform 2. | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | 0.613 |
| DKC1 | TEP1 | ENSPPYP00000023387 | ENSPPYP00000006332 | DKC1 isoform 2. | TEP1 isoform 2. | 0.529 |
| DKC1 | TERT | ENSPPYP00000023387 | ENSPPYP00000017108 | DKC1 isoform 2. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.997 |
| DKC1 | WRAP53 | ENSPPYP00000023387 | ENSPPYP00000009938 | DKC1 isoform 2. | WRAP53 isoform 2. | 0.999 |
| GAR1 | ACD | ENSPPYP00000016749 | ENSPPYP00000008431 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.736 |
| GAR1 | DKC1 | ENSPPYP00000016749 | ENSPPYP00000023387 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | DKC1 isoform 2. | 0.999 |
| GAR1 | NHP2 | ENSPPYP00000016749 | ENSPPYP00000018020 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.999 |
| GAR1 | NOP10 | ENSPPYP00000016749 | ENSPPYP00000007153 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | NOP10 ribonucleoprotein. | 0.999 |
