| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIMP1 | GARS1 | ENSPPYP00000016731 | ENSPPYP00000019811 | AIMP1 isoform 1. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.576 |
| AIMP1 | IARS1 | ENSPPYP00000016731 | ENSPPYP00000021711 | AIMP1 isoform 1. | IARS isoform 1; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.995 |
| AIMP1 | KARS1 | ENSPPYP00000016731 | ENSPPYP00000008540 | AIMP1 isoform 1. | Lysine--tRNA ligase. | 0.979 |
| AIMP1 | LARS1 | ENSPPYP00000016731 | ENSPPYP00000017795 | AIMP1 isoform 1. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.994 |
| AIMP1 | LARS2 | ENSPPYP00000016731 | ENSPPYP00000015598 | AIMP1 isoform 1. | Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.784 |
| AIMP1 | RARS1 | ENSPPYP00000016731 | ENSPPYP00000017935 | AIMP1 isoform 1. | Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. | 0.994 |
| AIMP1 | TARS1 | ENSPPYP00000016731 | ENSPPYP00000017181 | AIMP1 isoform 1. | TARS isoform 1. | 0.780 |
| AIMP1 | TARS2 | ENSPPYP00000016731 | ENSPPYP00000001051 | AIMP1 isoform 1. | TARS2 isoform 3. | 0.557 |
| AIMP1 | TARS3 | ENSPPYP00000016731 | ENSPPYP00000007749 | AIMP1 isoform 1. | TARSL2 isoform 1. | 0.870 |
| AIMP1 | YARS1 | ENSPPYP00000016731 | ENSPPYP00000001828 | AIMP1 isoform 1. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.714 |
| GARS1 | AIMP1 | ENSPPYP00000019811 | ENSPPYP00000016731 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | AIMP1 isoform 1. | 0.576 |
| GARS1 | IARS1 | ENSPPYP00000019811 | ENSPPYP00000021711 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | IARS isoform 1; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.928 |
| GARS1 | KARS1 | ENSPPYP00000019811 | ENSPPYP00000008540 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | Lysine--tRNA ligase. | 0.771 |
| GARS1 | LARS1 | ENSPPYP00000019811 | ENSPPYP00000017795 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.718 |
| GARS1 | LARS2 | ENSPPYP00000019811 | ENSPPYP00000015598 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.647 |
| GARS1 | RARS1 | ENSPPYP00000019811 | ENSPPYP00000017935 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. | 0.886 |
| GARS1 | TARS1 | ENSPPYP00000019811 | ENSPPYP00000017181 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | TARS isoform 1. | 0.820 |
| GARS1 | TARS2 | ENSPPYP00000019811 | ENSPPYP00000001051 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | TARS2 isoform 3. | 0.562 |
| GARS1 | TARS3 | ENSPPYP00000019811 | ENSPPYP00000007749 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | TARSL2 isoform 1. | 0.741 |
| GARS1 | YARS1 | ENSPPYP00000019811 | ENSPPYP00000001828 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.944 |
