| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LOC100437365 | NADK | ENSPPYP00000015838 | ENSPPYP00000002308 | Nicotinamide-nucleotide adenylyltransferase. | NADK isoform 1. | 0.945 |
| LOC100437365 | NADK2 | ENSPPYP00000015838 | ENSPPYP00000017204 | Nicotinamide-nucleotide adenylyltransferase. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | 0.923 |
| LOC100437365 | NADSYN1 | ENSPPYP00000015838 | ENSPPYP00000003421 | Nicotinamide-nucleotide adenylyltransferase. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.986 |
| LOC100437365 | NMNAT2 | ENSPPYP00000015838 | ENSPPYP00000000486 | Nicotinamide-nucleotide adenylyltransferase. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] | 0.941 |
| LOC100437365 | NNT | ENSPPYP00000015838 | ENSPPYP00000017255 | Nicotinamide-nucleotide adenylyltransferase. | Nicotinamide nucleotide transhydrogenase. | 0.908 |
| LOC100437365 | NUDT12 | ENSPPYP00000015838 | ENSPPYP00000017521 | Nicotinamide-nucleotide adenylyltransferase. | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | 0.919 |
| LOC100437365 | NUDT13 | ENSPPYP00000015838 | ENSPPYP00000002723 | Nicotinamide-nucleotide adenylyltransferase. | NUDT13 isoform 2. | 0.918 |
| LOC100437365 | SIRT3 | ENSPPYP00000015838 | ENSPPYP00000022355 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.926 |
| LOC100437365 | SIRT4 | ENSPPYP00000015838 | ENSPPYP00000005727 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.926 |
| LOC100437365 | SIRT5 | ENSPPYP00000015838 | ENSPPYP00000018164 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.923 |
| NADK | LOC100437365 | ENSPPYP00000002308 | ENSPPYP00000015838 | NADK isoform 1. | Nicotinamide-nucleotide adenylyltransferase. | 0.945 |
| NADK | NADK2 | ENSPPYP00000002308 | ENSPPYP00000017204 | NADK isoform 1. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | 0.950 |
| NADK | NADSYN1 | ENSPPYP00000002308 | ENSPPYP00000003421 | NADK isoform 1. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.956 |
| NADK | NMNAT2 | ENSPPYP00000002308 | ENSPPYP00000000486 | NADK isoform 1. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] | 0.948 |
| NADK | NNT | ENSPPYP00000002308 | ENSPPYP00000017255 | NADK isoform 1. | Nicotinamide nucleotide transhydrogenase. | 0.961 |
| NADK | NUDT12 | ENSPPYP00000002308 | ENSPPYP00000017521 | NADK isoform 1. | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | 0.917 |
| NADK | NUDT13 | ENSPPYP00000002308 | ENSPPYP00000002723 | NADK isoform 1. | NUDT13 isoform 2. | 0.912 |
| NADK | SIRT3 | ENSPPYP00000002308 | ENSPPYP00000022355 | NADK isoform 1. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.914 |
| NADK | SIRT4 | ENSPPYP00000002308 | ENSPPYP00000005727 | NADK isoform 1. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.914 |
| NADK | SIRT5 | ENSPPYP00000002308 | ENSPPYP00000018164 | NADK isoform 1. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.919 |
