NNT protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100437365	NADK	ENSPPYP00000015838	ENSPPYP00000002308	Nicotinamide-nucleotide adenylyltransferase.	NADK isoform 1.	0.945
LOC100437365	NADK2	ENSPPYP00000015838	ENSPPYP00000017204	Nicotinamide-nucleotide adenylyltransferase.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.923
LOC100437365	NADSYN1	ENSPPYP00000015838	ENSPPYP00000003421	Nicotinamide-nucleotide adenylyltransferase.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.986
LOC100437365	NMNAT2	ENSPPYP00000015838	ENSPPYP00000000486	Nicotinamide-nucleotide adenylyltransferase.	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...]	0.941
LOC100437365	NNT	ENSPPYP00000015838	ENSPPYP00000017255	Nicotinamide-nucleotide adenylyltransferase.	Nicotinamide nucleotide transhydrogenase.	0.908
LOC100437365	SARM1	ENSPPYP00000015838	ENSPPYP00000009100	Nicotinamide-nucleotide adenylyltransferase.	Sterile alpha and TIR motif containing 1.	0.973
LOC100437365	SIRT1	ENSPPYP00000015838	ENSPPYP00000002788	Nicotinamide-nucleotide adenylyltransferase.	SIRT1 isoform 1.	0.940
LOC100437365	SIRT2	ENSPPYP00000015838	ENSPPYP00000023731	Nicotinamide-nucleotide adenylyltransferase.	NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...]	0.913
LOC100437365	SIRT3	ENSPPYP00000015838	ENSPPYP00000022355	Nicotinamide-nucleotide adenylyltransferase.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.926
LOC100437365	SIRT7	ENSPPYP00000015838	ENSPPYP00000009825	Nicotinamide-nucleotide adenylyltransferase.	SIRT7 isoform 2.	0.919
NADK	LOC100437365	ENSPPYP00000002308	ENSPPYP00000015838	NADK isoform 1.	Nicotinamide-nucleotide adenylyltransferase.	0.945
NADK	NADK2	ENSPPYP00000002308	ENSPPYP00000017204	NADK isoform 1.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.950
NADK	NADSYN1	ENSPPYP00000002308	ENSPPYP00000003421	NADK isoform 1.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.956
NADK	NMNAT2	ENSPPYP00000002308	ENSPPYP00000000486	NADK isoform 1.	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...]	0.948
NADK	NNT	ENSPPYP00000002308	ENSPPYP00000017255	NADK isoform 1.	Nicotinamide nucleotide transhydrogenase.	0.961
NADK	SARM1	ENSPPYP00000002308	ENSPPYP00000009100	NADK isoform 1.	Sterile alpha and TIR motif containing 1.	0.928
NADK	SIRT1	ENSPPYP00000002308	ENSPPYP00000002788	NADK isoform 1.	SIRT1 isoform 1.	0.920
NADK	SIRT2	ENSPPYP00000002308	ENSPPYP00000023731	NADK isoform 1.	NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...]	0.914
NADK	SIRT3	ENSPPYP00000002308	ENSPPYP00000022355	NADK isoform 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.914
NADK	SIRT7	ENSPPYP00000002308	ENSPPYP00000009825	NADK isoform 1.	SIRT7 isoform 2.	0.914