| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BUB1 | BUB1B | ENSPPYP00000013551 | ENSPPYP00000007185 | BUB1 mitotic checkpoint serine/threonine kinase. | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | 0.999 |
| BUB1 | BUB3 | ENSPPYP00000013551 | ENSPPYP00000003192 | BUB1 mitotic checkpoint serine/threonine kinase. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.999 |
| BUB1 | CCNA2 | ENSPPYP00000013551 | ENSPPYP00000016798 | BUB1 mitotic checkpoint serine/threonine kinase. | CCNA2 isoform 1; Belongs to the cyclin family. | 0.977 |
| BUB1 | CDC20B | ENSPPYP00000013551 | ENSPPYP00000017282 | BUB1 mitotic checkpoint serine/threonine kinase. | CDC20B isoform 4. | 0.994 |
| BUB1 | CDK1 | ENSPPYP00000013551 | ENSPPYP00000002808 | BUB1 mitotic checkpoint serine/threonine kinase. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.994 |
| BUB1 | KIF2C | ENSPPYP00000013551 | ENSPPYP00000001652 | BUB1 mitotic checkpoint serine/threonine kinase. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.993 |
| BUB1 | MAD2L1 | ENSPPYP00000013551 | ENSPPYP00000016788 | BUB1 mitotic checkpoint serine/threonine kinase. | MAD2L1 isoform 1. | 0.999 |
| BUB1 | NEK2 | ENSPPYP00000013551 | ENSPPYP00000000250 | BUB1 mitotic checkpoint serine/threonine kinase. | NIMA related kinase 2. | 0.977 |
| BUB1 | PLK1 | ENSPPYP00000013551 | ENSPPYP00000008136 | BUB1 mitotic checkpoint serine/threonine kinase. | Serine/threonine-protein kinase PLK. | 0.998 |
| BUB1 | PTTG1 | ENSPPYP00000013551 | ENSPPYP00000017915 | BUB1 mitotic checkpoint serine/threonine kinase. | PTTG1 regulator of sister chromatid separation, securin. | 0.904 |
| BUB1B | BUB1 | ENSPPYP00000007185 | ENSPPYP00000013551 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.999 |
| BUB1B | BUB3 | ENSPPYP00000007185 | ENSPPYP00000003192 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.999 |
| BUB1B | CCNA2 | ENSPPYP00000007185 | ENSPPYP00000016798 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | CCNA2 isoform 1; Belongs to the cyclin family. | 0.983 |
| BUB1B | CDC20B | ENSPPYP00000007185 | ENSPPYP00000017282 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | CDC20B isoform 4. | 0.993 |
| BUB1B | CDK1 | ENSPPYP00000007185 | ENSPPYP00000002808 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.991 |
| BUB1B | KIF2C | ENSPPYP00000007185 | ENSPPYP00000001652 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.964 |
| BUB1B | MAD2L1 | ENSPPYP00000007185 | ENSPPYP00000016788 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | MAD2L1 isoform 1. | 0.999 |
| BUB1B | NEK2 | ENSPPYP00000007185 | ENSPPYP00000000250 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | NIMA related kinase 2. | 0.996 |
| BUB1B | PLK1 | ENSPPYP00000007185 | ENSPPYP00000008136 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | Serine/threonine-protein kinase PLK. | 0.998 |
| BUB1B | PTTG1 | ENSPPYP00000007185 | ENSPPYP00000017915 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | PTTG1 regulator of sister chromatid separation, securin. | 0.884 |
