STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC25A46SLC25A46 isoform 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)    
Predicted Functional Partners:
OPA1
Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intri [...]
   
 
 0.550
SLC25A16
SLC25A16 isoform 2; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.509
RASSF2
RASSF2 isoform 1.
      
 0.509
RAB2A
Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex.
      
 0.499
ITGB3BP
Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions.
      
 0.497
GDF10
Bone morphogenetic protein 3; Belongs to the TGF-beta family.
      
 0.457
TMEM232
TMEM232 isoform 9.
      
 0.457
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.