| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MAP3K7 | RIPK1 | ENSPPYP00000018861 | ENSPPYP00000018096 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | Receptor interacting serine/threonine kinase 1. | 0.990 |
| MAP3K7 | TICAM1 | ENSPPYP00000018861 | ENSPPYP00000010561 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.823 |
| MAP3K7 | TLR3 | ENSPPYP00000018861 | ENSPPYP00000017042 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.877 |
| MAP3K7 | TLR4 | ENSPPYP00000018861 | ENSPPYP00000021908 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.902 |
| MAP3K7 | TMED7-TICAM2 | ENSPPYP00000018861 | ENSPPYP00000017557 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | TICAM2 isoform 1. | 0.823 |
| MAP3K7 | TRAF3 | ENSPPYP00000018861 | ENSPPYP00000007003 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.957 |
| MAP3K7 | TRAF6 | ENSPPYP00000018861 | ENSPPYP00000003845 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
| RIPK1 | MAP3K7 | ENSPPYP00000018096 | ENSPPYP00000018861 | Receptor interacting serine/threonine kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.990 |
| RIPK1 | TICAM1 | ENSPPYP00000018096 | ENSPPYP00000010561 | Receptor interacting serine/threonine kinase 1. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.974 |
| RIPK1 | TLR3 | ENSPPYP00000018096 | ENSPPYP00000017042 | Receptor interacting serine/threonine kinase 1. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.935 |
| RIPK1 | TLR4 | ENSPPYP00000018096 | ENSPPYP00000021908 | Receptor interacting serine/threonine kinase 1. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.699 |
| RIPK1 | TMED7-TICAM2 | ENSPPYP00000018096 | ENSPPYP00000017557 | Receptor interacting serine/threonine kinase 1. | TICAM2 isoform 1. | 0.974 |
| RIPK1 | TRAF3 | ENSPPYP00000018096 | ENSPPYP00000007003 | Receptor interacting serine/threonine kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.773 |
| RIPK1 | TRAF6 | ENSPPYP00000018096 | ENSPPYP00000003845 | Receptor interacting serine/threonine kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.996 |
| TICAM1 | MAP3K7 | ENSPPYP00000010561 | ENSPPYP00000018861 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.823 |
| TICAM1 | RIPK1 | ENSPPYP00000010561 | ENSPPYP00000018096 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Receptor interacting serine/threonine kinase 1. | 0.974 |
| TICAM1 | TLR2 | ENSPPYP00000010561 | ENSPPYP00000016910 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Toll-like receptor. | 0.936 |
| TICAM1 | TLR3 | ENSPPYP00000010561 | ENSPPYP00000017042 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.983 |
| TICAM1 | TLR4 | ENSPPYP00000010561 | ENSPPYP00000021908 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.987 |
| TICAM1 | TMED10 | ENSPPYP00000010561 | ENSPPYP00000024352 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.847 |
