| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FIP1L1 | P4HA1 | ENSPPYP00000016499 | ENSPPYP00000002727 | Pre-mRNA 3'-end-processing factor FIP1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | 0.622 |
| FIP1L1 | P4HA2 | ENSPPYP00000016499 | ENSPPYP00000017621 | Pre-mRNA 3'-end-processing factor FIP1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). | Prolyl 4-hydroxylase subunit alpha 2. | 0.799 |
| FIP1L1 | P4HA3 | ENSPPYP00000016499 | ENSPPYP00000004198 | Pre-mRNA 3'-end-processing factor FIP1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). | Prolyl 4-hydroxylase subunit alpha 3. | 0.404 |
| LAP3 | P4HA1 | ENSPPYP00000016340 | ENSPPYP00000002727 | Leucine aminopeptidase 3. | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | 0.902 |
| LAP3 | P4HA2 | ENSPPYP00000016340 | ENSPPYP00000017621 | Leucine aminopeptidase 3. | Prolyl 4-hydroxylase subunit alpha 2. | 0.902 |
| LAP3 | P4HA3 | ENSPPYP00000016340 | ENSPPYP00000004198 | Leucine aminopeptidase 3. | Prolyl 4-hydroxylase subunit alpha 3. | 0.902 |
| LAP3 | PRODH | ENSPPYP00000016340 | ENSPPYP00000013433 | Leucine aminopeptidase 3. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.900 |
| LAP3 | PYCR1 | ENSPPYP00000016340 | ENSPPYP00000009827 | Leucine aminopeptidase 3. | Pyrroline-5-carboxylate reductase 1, mitochondrial; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Belongs to the pyrroline-5-carboxylate reductase family. | 0.906 |
| LAP3 | PYCR2 | ENSPPYP00000016340 | ENSPPYP00000000169 | Leucine aminopeptidase 3. | Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity); Belongs to the pyrroline-5-carboxylate reductase family. | 0.906 |
| LAP3 | PYCR3 | ENSPPYP00000016340 | ENSPPYP00000021245 | Leucine aminopeptidase 3. | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. | 0.921 |
| P4HA1 | FIP1L1 | ENSPPYP00000002727 | ENSPPYP00000016499 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Pre-mRNA 3'-end-processing factor FIP1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). | 0.622 |
| P4HA1 | LAP3 | ENSPPYP00000002727 | ENSPPYP00000016340 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Leucine aminopeptidase 3. | 0.902 |
| P4HA1 | P4HA2 | ENSPPYP00000002727 | ENSPPYP00000017621 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Prolyl 4-hydroxylase subunit alpha 2. | 0.927 |
| P4HA1 | P4HA3 | ENSPPYP00000002727 | ENSPPYP00000004198 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Prolyl 4-hydroxylase subunit alpha 3. | 0.910 |
| P4HA1 | P4HB | ENSPPYP00000002727 | ENSPPYP00000009818 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] | 0.934 |
| P4HA1 | PRODH | ENSPPYP00000002727 | ENSPPYP00000013433 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.910 |
| P4HA1 | PRODH2 | ENSPPYP00000002727 | ENSPPYP00000024465 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.910 |
| P4HA1 | PYCR1 | ENSPPYP00000002727 | ENSPPYP00000009827 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Pyrroline-5-carboxylate reductase 1, mitochondrial; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Belongs to the pyrroline-5-carboxylate reductase family. | 0.905 |
| P4HA1 | PYCR2 | ENSPPYP00000002727 | ENSPPYP00000000169 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity); Belongs to the pyrroline-5-carboxylate reductase family. | 0.905 |
| P4HA1 | PYCR3 | ENSPPYP00000002727 | ENSPPYP00000021245 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. | 0.928 |
