| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHD4 | EP300 | ENSPPYP00000004777 | ENSPPYP00000013236 | CHD4 isoform 1. | EP300 isoform 1. | 0.771 |
| CHD4 | HDAC1 | ENSPPYP00000004777 | ENSPPYP00000001838 | CHD4 isoform 1. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.995 |
| CHD4 | IRF1 | ENSPPYP00000004777 | ENSPPYP00000017628 | CHD4 isoform 1. | Interferon regulatory factor. | 0.904 |
| EP300 | CHD4 | ENSPPYP00000013236 | ENSPPYP00000004777 | EP300 isoform 1. | CHD4 isoform 1. | 0.771 |
| EP300 | HDAC1 | ENSPPYP00000013236 | ENSPPYP00000001838 | EP300 isoform 1. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.976 |
| EP300 | IRF1 | ENSPPYP00000013236 | ENSPPYP00000017628 | EP300 isoform 1. | Interferon regulatory factor. | 0.881 |
| EP300 | MDM2 | ENSPPYP00000013236 | ENSPPYP00000005415 | EP300 isoform 1. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.904 |
| EP300 | STAT1 | ENSPPYP00000013236 | ENSPPYP00000014555 | EP300 isoform 1. | Signal transducer and activator of transcription. | 0.996 |
| EP300 | STAT3 | ENSPPYP00000013236 | ENSPPYP00000009437 | EP300 isoform 1. | Signal transducer and activator of transcription. | 0.998 |
| EP300 | STAT4 | ENSPPYP00000013236 | ENSPPYP00000014556 | EP300 isoform 1. | Signal transducer and activator of transcription. | 0.980 |
| HDAC1 | CHD4 | ENSPPYP00000001838 | ENSPPYP00000004777 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | CHD4 isoform 1. | 0.995 |
| HDAC1 | EP300 | ENSPPYP00000001838 | ENSPPYP00000013236 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | EP300 isoform 1. | 0.976 |
| HDAC1 | IRF1 | ENSPPYP00000001838 | ENSPPYP00000017628 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Interferon regulatory factor. | 0.920 |
| HDAC1 | MDM2 | ENSPPYP00000001838 | ENSPPYP00000005415 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.753 |
| HDAC1 | STAT1 | ENSPPYP00000001838 | ENSPPYP00000014555 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Signal transducer and activator of transcription. | 0.596 |
| HDAC1 | STAT3 | ENSPPYP00000001838 | ENSPPYP00000009437 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Signal transducer and activator of transcription. | 0.898 |
| HDAC1 | STAT4 | ENSPPYP00000001838 | ENSPPYP00000014556 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Signal transducer and activator of transcription. | 0.529 |
| IRF1 | CHD4 | ENSPPYP00000017628 | ENSPPYP00000004777 | Interferon regulatory factor. | CHD4 isoform 1. | 0.904 |
| IRF1 | EP300 | ENSPPYP00000017628 | ENSPPYP00000013236 | Interferon regulatory factor. | EP300 isoform 1. | 0.881 |
| IRF1 | HDAC1 | ENSPPYP00000017628 | ENSPPYP00000001838 | Interferon regulatory factor. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.920 |
