| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0053238 | CUL3 | ENSPPYP00000011907 | ENSPPYP00000014786 | KLHL17 isoform 2. | CUL3 isoform 1; Belongs to the cullin family. | 0.928 |
| CR201_G0053238 | FBXL17 | ENSPPYP00000011907 | ENSPPYP00000017523 | KLHL17 isoform 2. | FBXL17 isoform 1. | 0.731 |
| CR201_G0053238 | KLHL12 | ENSPPYP00000011907 | ENSPPYP00000000380 | KLHL17 isoform 2. | KLHL12 isoform 2. | 0.747 |
| CR201_G0053238 | KLHL2 | ENSPPYP00000011907 | ENSPPYP00000016958 | KLHL17 isoform 2. | KLHL2 isoform 2. | 0.766 |
| CR201_G0053238 | KLHL3 | ENSPPYP00000011907 | ENSPPYP00000017680 | KLHL17 isoform 2. | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). | 0.645 |
| CR201_G0053238 | RBX1 | ENSPPYP00000011907 | ENSPPYP00000013235 | KLHL17 isoform 2. | RBX1 isoform 1. | 0.913 |
| CUL3 | CR201_G0053238 | ENSPPYP00000014786 | ENSPPYP00000011907 | CUL3 isoform 1; Belongs to the cullin family. | KLHL17 isoform 2. | 0.928 |
| CUL3 | FBXL17 | ENSPPYP00000014786 | ENSPPYP00000017523 | CUL3 isoform 1; Belongs to the cullin family. | FBXL17 isoform 1. | 0.599 |
| CUL3 | KEAP1 | ENSPPYP00000014786 | ENSPPYP00000010716 | CUL3 isoform 1; Belongs to the cullin family. | Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] | 0.994 |
| CUL3 | KLHL12 | ENSPPYP00000014786 | ENSPPYP00000000380 | CUL3 isoform 1; Belongs to the cullin family. | KLHL12 isoform 2. | 0.994 |
| CUL3 | KLHL2 | ENSPPYP00000014786 | ENSPPYP00000016958 | CUL3 isoform 1; Belongs to the cullin family. | KLHL2 isoform 2. | 0.965 |
| CUL3 | KLHL3 | ENSPPYP00000014786 | ENSPPYP00000017680 | CUL3 isoform 1; Belongs to the cullin family. | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). | 0.979 |
| CUL3 | RBX1 | ENSPPYP00000014786 | ENSPPYP00000013235 | CUL3 isoform 1; Belongs to the cullin family. | RBX1 isoform 1. | 0.998 |
| CUL3 | WNK1 | ENSPPYP00000014786 | ENSPPYP00000023617 | CUL3 isoform 1; Belongs to the cullin family. | WNK1 isoform 4. | 0.662 |
| CUL3 | WNK3 | ENSPPYP00000014786 | ENSPPYP00000022813 | CUL3 isoform 1; Belongs to the cullin family. | WNK3 isoform 2. | 0.462 |
| CUL3 | WNK4 | ENSPPYP00000014786 | ENSPPYP00000009418 | CUL3 isoform 1; Belongs to the cullin family. | WNK4 isoform 3. | 0.892 |
| FBXL17 | CR201_G0053238 | ENSPPYP00000017523 | ENSPPYP00000011907 | FBXL17 isoform 1. | KLHL17 isoform 2. | 0.731 |
| FBXL17 | CUL3 | ENSPPYP00000017523 | ENSPPYP00000014786 | FBXL17 isoform 1. | CUL3 isoform 1; Belongs to the cullin family. | 0.599 |
| FBXL17 | KEAP1 | ENSPPYP00000017523 | ENSPPYP00000010716 | FBXL17 isoform 1. | Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] | 0.747 |
| FBXL17 | KLHL12 | ENSPPYP00000017523 | ENSPPYP00000000380 | FBXL17 isoform 1. | KLHL12 isoform 2. | 0.948 |
