| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCE1 | ETF1 | ENSPPYP00000016865 | ENSPPYP00000017698 | ABCE1 isoform 1. | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | 0.980 |
| ABCE1 | GSPT1 | ENSPPYP00000016865 | ENSPPYP00000008043 | ABCE1 isoform 1. | GSPT1 isoform 2. | 0.723 |
| ABCE1 | GSPT2 | ENSPPYP00000016865 | ENSPPYP00000022791 | ABCE1 isoform 1. | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). | 0.723 |
| ABCE1 | RPL8 | ENSPPYP00000016865 | ENSPPYP00000021297 | ABCE1 isoform 1. | 60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family. | 0.600 |
| ABCE1 | RPS3 | ENSPPYP00000016865 | ENSPPYP00000004215 | ABCE1 isoform 1. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.935 |
| ABCE1 | RPS5 | ENSPPYP00000016865 | ENSPPYP00000024669 | ABCE1 isoform 1. | RPS5 isoform 1; Belongs to the universal ribosomal protein uS7 family. | 0.919 |
| ABCE1 | UPF1 | ENSPPYP00000016865 | ENSPPYP00000010923 | ABCE1 isoform 1. | UPF1 isoform 2. | 0.479 |
| CR201_G0030893 | ETF1 | ENSPPYP00000000152 | ENSPPYP00000017698 | JMJD4 isoform 1. | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | 0.973 |
| CR201_G0047047 | ETF1 | ENSPPYP00000008730 | ENSPPYP00000017698 | SMG1 isoform 2. | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | 0.871 |
| CR201_G0047047 | GSPT1 | ENSPPYP00000008730 | ENSPPYP00000008043 | SMG1 isoform 2. | GSPT1 isoform 2. | 0.688 |
| CR201_G0047047 | GSPT2 | ENSPPYP00000008730 | ENSPPYP00000022791 | SMG1 isoform 2. | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). | 0.688 |
| CR201_G0047047 | SMG1 | ENSPPYP00000008730 | ENSPPYP00000008072 | SMG1 isoform 2. | SMG1 isoform 8; Belongs to the PI3/PI4-kinase family. | 0.916 |
| CR201_G0047047 | UPF1 | ENSPPYP00000008730 | ENSPPYP00000010923 | SMG1 isoform 2. | UPF1 isoform 2. | 0.880 |
| ETF1 | ABCE1 | ENSPPYP00000017698 | ENSPPYP00000016865 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | ABCE1 isoform 1. | 0.980 |
| ETF1 | CR201_G0030893 | ENSPPYP00000017698 | ENSPPYP00000000152 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | JMJD4 isoform 1. | 0.973 |
| ETF1 | CR201_G0047047 | ENSPPYP00000017698 | ENSPPYP00000008730 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | SMG1 isoform 2. | 0.871 |
| ETF1 | GSPT1 | ENSPPYP00000017698 | ENSPPYP00000008043 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | GSPT1 isoform 2. | 0.963 |
| ETF1 | GSPT2 | ENSPPYP00000017698 | ENSPPYP00000022791 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). | 0.963 |
| ETF1 | RPL8 | ENSPPYP00000017698 | ENSPPYP00000021297 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | 60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family. | 0.889 |
| ETF1 | RPS3 | ENSPPYP00000017698 | ENSPPYP00000004215 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.860 |
