STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCTN4Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (By similarity) (460 aa)    
Predicted Functional Partners:
DCTN5
Pongo abelii dynactin 5 (p25) (DCTN5), mRNA; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily
   
 0.993
DCTN2
Uncharacterized protein; Pongo abelii dynactin 2 (p50) (DCTN2), mRNA
   
 0.992
DCTN6
Pongo abelii dynactin 6 (DCTN6), mRNA
    
 0.990
ACTR10
Actin-related protein 10 homolog (S. cerevisiae); Belongs to the actin family
   
 
 0.935
DCTN1
Dynactin 1
   
 
 0.919
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Belongs to the actin family
   
 
 0.870
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Belongs to the actin family
   
 
 0.852
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity)
   
 
 0.832
DCTN3
Dynactin 3 (p22)
   
 
 0.740
RPS19BP1
Ribosomal protein S19 binding protein 1
    
   0.713
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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