STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TENM2TENM2 isoform 3. (2577 aa)    
Predicted Functional Partners:
ADGRL1
ADGRL1 isoform 1; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.972
ADGRL2
ADGRL2 isoform 14; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.958
ADGRL3
ADGRL3 isoform 1; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.958
ROBO1
ROBO1 isoform 6.
   
  
 0.797
ROBO2
ROBO2 isoform 6.
   
  
 0.792
NPAS3
NPAS3 isoform 2.
    
 
 0.707
FLRT3
Leucine-rich repeat transmembrane protein FLRT3; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (By similarity). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expres [...]
   
 
 0.682
FOXP2
FOXP2 isoform 11.
      
 0.668
HARS1
Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family.
      
 0.658
CR201_G0037836
TENM3 isoform 2.
 
      0.564
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.