MSX2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MSX2

MSX2 isoform 1. (269 aa)

Predicted Functional Partners:

MSX1

0.943

RUNX2

0.930

SPEN

0.692

TWIST1

0.687

DLX5

0.682

SPDEF

0.677

BMP4

0.643

TFAP2C

0.641

CD151

0.612

PAX9

0.557

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	DLX5	ENSPPYP00000006620	ENSPPYP00000019945	Bone morphogenetic protein 4.	Distal-less homeobox 5.	0.663
BMP4	MSX1	ENSPPYP00000006620	ENSPPYP00000016306	Bone morphogenetic protein 4.	MSX1 isoform 1.	0.682
BMP4	MSX2	ENSPPYP00000006620	ENSPPYP00000017974	Bone morphogenetic protein 4.	MSX2 isoform 1.	0.643
BMP4	PAX9	ENSPPYP00000006620	ENSPPYP00000006537	Bone morphogenetic protein 4.	PAX9 isoform 1.	0.580
BMP4	RUNX2	ENSPPYP00000006620	ENSPPYP00000018641	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.733
BMP4	TFAP2C	ENSPPYP00000006620	ENSPPYP00000012464	Bone morphogenetic protein 4.	TFAP2C isoform 1.	0.443
CD151	MSX2	ENSPPYP00000003360	ENSPPYP00000017974	Tetraspanin.	MSX2 isoform 1.	0.612
CD151	SPDEF	ENSPPYP00000003360	ENSPPYP00000018471	Tetraspanin.	SPDEF isoform 2.	0.709
DLX5	BMP4	ENSPPYP00000019945	ENSPPYP00000006620	Distal-less homeobox 5.	Bone morphogenetic protein 4.	0.663
DLX5	MSX2	ENSPPYP00000019945	ENSPPYP00000017974	Distal-less homeobox 5.	MSX2 isoform 1.	0.682
DLX5	RUNX2	ENSPPYP00000019945	ENSPPYP00000018641	Distal-less homeobox 5.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.908
MSX1	BMP4	ENSPPYP00000016306	ENSPPYP00000006620	MSX1 isoform 1.	Bone morphogenetic protein 4.	0.682
MSX1	MSX2	ENSPPYP00000016306	ENSPPYP00000017974	MSX1 isoform 1.	MSX2 isoform 1.	0.943
MSX1	PAX9	ENSPPYP00000016306	ENSPPYP00000006537	MSX1 isoform 1.	PAX9 isoform 1.	0.824
MSX1	RUNX2	ENSPPYP00000016306	ENSPPYP00000018641	MSX1 isoform 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.631
MSX2	BMP4	ENSPPYP00000017974	ENSPPYP00000006620	MSX2 isoform 1.	Bone morphogenetic protein 4.	0.643
MSX2	CD151	ENSPPYP00000017974	ENSPPYP00000003360	MSX2 isoform 1.	Tetraspanin.	0.612
MSX2	DLX5	ENSPPYP00000017974	ENSPPYP00000019945	MSX2 isoform 1.	Distal-less homeobox 5.	0.682
MSX2	MSX1	ENSPPYP00000017974	ENSPPYP00000016306	MSX2 isoform 1.	MSX1 isoform 1.	0.943
MSX2	PAX9	ENSPPYP00000017974	ENSPPYP00000006537	MSX2 isoform 1.	PAX9 isoform 1.	0.557