FAF2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FAF2

Fas associated factor family member 2. (445 aa)

Predicted Functional Partners:

VCP

0.998

UFD1

0.997

NPLOC4

0.997

UBXN1

0.995

UBAC2

0.995

UBXN7

0.995

BAG6

0.987

MAGED1

0.987

AMFR

0.954

DERL2

0.950

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	BAG6	ENSPPYP00000008318	ENSPPYP00000018388	AMFR isoform 1.	BCL2 associated athanogene 6.	0.869
AMFR	DERL2	ENSPPYP00000008318	ENSPPYP00000008861	AMFR isoform 1.	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	0.960
AMFR	FAF2	ENSPPYP00000008318	ENSPPYP00000017988	AMFR isoform 1.	Fas associated factor family member 2.	0.954
AMFR	NPLOC4	ENSPPYP00000008318	ENSPPYP00000024006	AMFR isoform 1.	NPLOC4 isoform 1.	0.606
AMFR	UBAC2	ENSPPYP00000008318	ENSPPYP00000006232	AMFR isoform 1.	UBAC2 isoform 5.	0.890
AMFR	UBXN1	ENSPPYP00000008318	ENSPPYP00000003643	AMFR isoform 1.	UBXN1 isoform 1.	0.929
AMFR	UBXN7	ENSPPYP00000008318	ENSPPYP00000016149	AMFR isoform 1.	UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity).	0.516
AMFR	UFD1	ENSPPYP00000008318	ENSPPYP00000012917	AMFR isoform 1.	Ubiquitin recognition factor in ER associated degradation 1.	0.715
AMFR	VCP	ENSPPYP00000008318	ENSPPYP00000021408	AMFR isoform 1.	Transitional endoplasmic reticulum ATPase isoform X1.	0.991
BAG6	AMFR	ENSPPYP00000018388	ENSPPYP00000008318	BCL2 associated athanogene 6.	AMFR isoform 1.	0.869
BAG6	FAF2	ENSPPYP00000018388	ENSPPYP00000017988	BCL2 associated athanogene 6.	Fas associated factor family member 2.	0.987
BAG6	UBXN1	ENSPPYP00000018388	ENSPPYP00000003643	BCL2 associated athanogene 6.	UBXN1 isoform 1.	0.988
BAG6	VCP	ENSPPYP00000018388	ENSPPYP00000021408	BCL2 associated athanogene 6.	Transitional endoplasmic reticulum ATPase isoform X1.	0.631
DERL2	AMFR	ENSPPYP00000008861	ENSPPYP00000008318	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	AMFR isoform 1.	0.960
DERL2	FAF2	ENSPPYP00000008861	ENSPPYP00000017988	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	Fas associated factor family member 2.	0.950
DERL2	NPLOC4	ENSPPYP00000008861	ENSPPYP00000024006	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	NPLOC4 isoform 1.	0.774
DERL2	UBAC2	ENSPPYP00000008861	ENSPPYP00000006232	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	UBAC2 isoform 5.	0.508
DERL2	UBXN1	ENSPPYP00000008861	ENSPPYP00000003643	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	UBXN1 isoform 1.	0.764
DERL2	UFD1	ENSPPYP00000008861	ENSPPYP00000012917	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	Ubiquitin recognition factor in ER associated degradation 1.	0.854
DERL2	VCP	ENSPPYP00000008861	ENSPPYP00000021408	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	Transitional endoplasmic reticulum ATPase isoform X1.	0.980