Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EDN1EDN1 isoform 1. (212 aa)    
Predicted Functional Partners:
EDNRA
EDNRA isoform 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.999
EDNRB
Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.
    
 0.999
EDN2
EDN2 isoform 2.
   
 
0.946
MMP9
MMP9 isoform 1.
     
 0.938
BDKRB2
Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family.
    
 0.935
BDKRB1
B1 bradykinin receptor isoform X2.
    
 0.934
EDN3
EDN3 isoform 1.
     
0.933
AGTR2
Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.
    
 0.828
OXTR
Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
    
 0.821
AVPR1A
Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
    
 0.783
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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