node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYCS | NDUFA9 | ENSPPYP00000019862 | ENSPPYP00000004753 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.454 |
CYCS | SIRT3 | ENSPPYP00000019862 | ENSPPYP00000022355 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.507 |
CYCS | SIRT5 | ENSPPYP00000019862 | ENSPPYP00000018164 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.874 |
H3-4 | H3C13 | ENSPPYP00000000136 | ENSPPYP00000022371 | Histone H3; Belongs to the histone H3 family. | Histone H3. | 0.899 |
H3-4 | LOC100436122-8 | ENSPPYP00000000136 | ENSPPYP00000023510 | Histone H3; Belongs to the histone H3 family. | Histone H3.1. | 0.910 |
H3-4 | LOC100449918 | ENSPPYP00000000136 | ENSPPYP00000001074 | Histone H3; Belongs to the histone H3 family. | HIST2H3C isoform 1. | 0.899 |
H3-4 | RRP8 | ENSPPYP00000000136 | ENSPPYP00000004057 | Histone H3; Belongs to the histone H3 family. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.427 |
H3-4 | SIRT3 | ENSPPYP00000000136 | ENSPPYP00000022355 | Histone H3; Belongs to the histone H3 family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.917 |
H3-4 | SIRT5 | ENSPPYP00000000136 | ENSPPYP00000018164 | Histone H3; Belongs to the histone H3 family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.919 |
H3C13 | H3-4 | ENSPPYP00000022371 | ENSPPYP00000000136 | Histone H3. | Histone H3; Belongs to the histone H3 family. | 0.899 |
H3C13 | LOC100436122-8 | ENSPPYP00000022371 | ENSPPYP00000023510 | Histone H3. | Histone H3.1. | 0.942 |
H3C13 | LOC100449918 | ENSPPYP00000022371 | ENSPPYP00000001074 | Histone H3. | HIST2H3C isoform 1. | 0.900 |
H3C13 | SIRT3 | ENSPPYP00000022371 | ENSPPYP00000022355 | Histone H3. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.736 |
H3C13 | SIRT5 | ENSPPYP00000022371 | ENSPPYP00000018164 | Histone H3. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.745 |
IDH2 | SIRT3 | ENSPPYP00000007685 | ENSPPYP00000022355 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.779 |
IDH2 | SIRT5 | ENSPPYP00000007685 | ENSPPYP00000018164 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.639 |
LOC100436122-8 | H3-4 | ENSPPYP00000023510 | ENSPPYP00000000136 | Histone H3.1. | Histone H3; Belongs to the histone H3 family. | 0.910 |
LOC100436122-8 | H3C13 | ENSPPYP00000023510 | ENSPPYP00000022371 | Histone H3.1. | Histone H3. | 0.942 |
LOC100436122-8 | LOC100449918 | ENSPPYP00000023510 | ENSPPYP00000001074 | Histone H3.1. | HIST2H3C isoform 1. | 0.942 |
LOC100436122-8 | SIRT3 | ENSPPYP00000023510 | ENSPPYP00000022355 | Histone H3.1. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.897 |