HFE protein (Pongo abelii) - STRING interaction network

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Score

HFE

Homeostatic iron regulator; Belongs to the MHC class I family. (348 aa)

Predicted Functional Partners:

TFRC

0.998

TFR2

0.993

HJV

0.898

B2M

0.862

HAMP

0.784

EPO

0.713

RPA2

0.691

TMPRSS6

0.690

SLC40A1

0.687

SLC11A2

0.686

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	HFE	ENSPPYP00000007289	ENSPPYP00000018234	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.862
B2M	TFR2	ENSPPYP00000007289	ENSPPYP00000019526	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	TFR2 isoform 2.	0.591
B2M	TFRC	ENSPPYP00000007289	ENSPPYP00000016144	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).	0.703
EPO	HFE	ENSPPYP00000019531	ENSPPYP00000018234	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.713
EPO	SLC11A2	ENSPPYP00000019531	ENSPPYP00000024385	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	SLC11A2 isoform 12.	0.427
EPO	TMPRSS6	ENSPPYP00000019531	ENSPPYP00000013149	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	TMPRSS6 isoform 2; Belongs to the peptidase S1 family.	0.438
HAMP	HFE	ENSPPYP00000011035	ENSPPYP00000018234	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.784
HAMP	HJV	ENSPPYP00000011035	ENSPPYP00000001079	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	HFE2 isoform 3.	0.817
HAMP	SLC11A2	ENSPPYP00000011035	ENSPPYP00000024385	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	SLC11A2 isoform 12.	0.790
HAMP	SLC40A1	ENSPPYP00000011035	ENSPPYP00000014539	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.995
HAMP	TFR2	ENSPPYP00000011035	ENSPPYP00000019526	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	TFR2 isoform 2.	0.709
HAMP	TFRC	ENSPPYP00000011035	ENSPPYP00000016144	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).	0.690
HAMP	TMPRSS6	ENSPPYP00000011035	ENSPPYP00000013149	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	TMPRSS6 isoform 2; Belongs to the peptidase S1 family.	0.863
HFE	B2M	ENSPPYP00000018234	ENSPPYP00000007289	Homeostatic iron regulator; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.862
HFE	EPO	ENSPPYP00000018234	ENSPPYP00000019531	Homeostatic iron regulator; Belongs to the MHC class I family.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.713
HFE	HAMP	ENSPPYP00000018234	ENSPPYP00000011035	Homeostatic iron regulator; Belongs to the MHC class I family.	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family.	0.784
HFE	HJV	ENSPPYP00000018234	ENSPPYP00000001079	Homeostatic iron regulator; Belongs to the MHC class I family.	HFE2 isoform 3.	0.898
HFE	RPA2	ENSPPYP00000018234	ENSPPYP00000001907	Homeostatic iron regulator; Belongs to the MHC class I family.	Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...]	0.691
HFE	SLC11A2	ENSPPYP00000018234	ENSPPYP00000024385	Homeostatic iron regulator; Belongs to the MHC class I family.	SLC11A2 isoform 12.	0.686
HFE	SLC40A1	ENSPPYP00000018234	ENSPPYP00000014539	Homeostatic iron regulator; Belongs to the MHC class I family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.687