MSH5 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MSH5	ENSPPYP00000022265	ENSPPYP00000018401	Tyrosine-protein kinase.	MSH5 isoform 1.	0.748
BLM	CR201_G0050730	ENSPPYP00000007694	ENSPPYP00000009055	BLM isoform 1.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.999
BLM	EXO1	ENSPPYP00000007694	ENSPPYP00000000064	BLM isoform 1.	EXO1 isoform 1.	0.984
BLM	MLH1	ENSPPYP00000007694	ENSPPYP00000015683	BLM isoform 1.	MLH1 isoform 1.	0.964
BLM	MLH3	ENSPPYP00000007694	ENSPPYP00000006818	BLM isoform 1.	MLH3 isoform 1.	0.706
BLM	MSH5	ENSPPYP00000007694	ENSPPYP00000018401	BLM isoform 1.	MSH5 isoform 1.	0.776
CR201_G0050730	BLM	ENSPPYP00000009055	ENSPPYP00000007694	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	BLM isoform 1.	0.999
CR201_G0050730	EXO1	ENSPPYP00000009055	ENSPPYP00000000064	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	EXO1 isoform 1.	0.844
CR201_G0050730	MLH1	ENSPPYP00000009055	ENSPPYP00000015683	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	MLH1 isoform 1.	0.786
CR201_G0050730	MLH3	ENSPPYP00000009055	ENSPPYP00000006818	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	MLH3 isoform 1.	0.619
CR201_G0050730	MSH5	ENSPPYP00000009055	ENSPPYP00000018401	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	MSH5 isoform 1.	0.784
CR201_G0053891	EXO1	ENSPPYP00000019636	ENSPPYP00000000064	PMS2 isoform 6.	EXO1 isoform 1.	0.829
CR201_G0053891	MLH1	ENSPPYP00000019636	ENSPPYP00000015683	PMS2 isoform 6.	MLH1 isoform 1.	0.976
CR201_G0053891	MLH3	ENSPPYP00000019636	ENSPPYP00000006818	PMS2 isoform 6.	MLH3 isoform 1.	0.719
CR201_G0053891	MSH5	ENSPPYP00000019636	ENSPPYP00000018401	PMS2 isoform 6.	MSH5 isoform 1.	0.745
CR201_G0053891	PMS1	ENSPPYP00000019636	ENSPPYP00000014543	PMS2 isoform 6.	PMS1 isoform 2.	0.757
ENSPPYP00000020441	EXO1	ENSPPYP00000020441	ENSPPYP00000000064	annotation not available	EXO1 isoform 1.	0.829
ENSPPYP00000020441	MLH1	ENSPPYP00000020441	ENSPPYP00000015683	annotation not available	MLH1 isoform 1.	0.947
ENSPPYP00000020441	MLH3	ENSPPYP00000020441	ENSPPYP00000006818	annotation not available	MLH3 isoform 1.	0.415
ENSPPYP00000020441	MSH5	ENSPPYP00000020441	ENSPPYP00000018401	annotation not available	MSH5 isoform 1.	0.747