| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBX3 | CBX5 | ENSPPYP00000019856 | ENSPPYP00000005247 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | CBX5 isoform 2. | 0.921 |
| CBX3 | CDYL | ENSPPYP00000019856 | ENSPPYP00000018112 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Chromodomain Y like. | 0.432 |
| CBX3 | EHMT1 | ENSPPYP00000019856 | ENSPPYP00000022240 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | EHMT1 isoform 1. | 0.856 |
| CBX3 | EHMT2 | ENSPPYP00000019856 | ENSPPYP00000018412 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | EHMT2 isoform 5. | 0.929 |
| CBX3 | HDAC1 | ENSPPYP00000019856 | ENSPPYP00000001838 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.460 |
| CBX3 | HDAC2 | ENSPPYP00000019856 | ENSPPYP00000018964 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone deacetylase 2. | 0.455 |
| CBX3 | KDM1A | ENSPPYP00000019856 | ENSPPYP00000002023 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.445 |
| CBX5 | CBX3 | ENSPPYP00000005247 | ENSPPYP00000019856 | CBX5 isoform 2. | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.921 |
| CBX5 | CR201_G0037536 | ENSPPYP00000005247 | ENSPPYP00000010840 | CBX5 isoform 2. | WIZ isoform 3. | 0.733 |
| CBX5 | EHMT1 | ENSPPYP00000005247 | ENSPPYP00000022240 | CBX5 isoform 2. | EHMT1 isoform 1. | 0.826 |
| CBX5 | EHMT2 | ENSPPYP00000005247 | ENSPPYP00000018412 | CBX5 isoform 2. | EHMT2 isoform 5. | 0.899 |
| CBX5 | KDM1A | ENSPPYP00000005247 | ENSPPYP00000002023 | CBX5 isoform 2. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.445 |
| CDYL | CBX3 | ENSPPYP00000018112 | ENSPPYP00000019856 | Chromodomain Y like. | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.432 |
| CDYL | CR201_G0037536 | ENSPPYP00000018112 | ENSPPYP00000010840 | Chromodomain Y like. | WIZ isoform 3. | 0.838 |
| CDYL | EHMT1 | ENSPPYP00000018112 | ENSPPYP00000022240 | Chromodomain Y like. | EHMT1 isoform 1. | 0.877 |
| CDYL | EHMT2 | ENSPPYP00000018112 | ENSPPYP00000018412 | Chromodomain Y like. | EHMT2 isoform 5. | 0.913 |
| CDYL | HDAC1 | ENSPPYP00000018112 | ENSPPYP00000001838 | Chromodomain Y like. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.834 |
| CDYL | HDAC2 | ENSPPYP00000018112 | ENSPPYP00000018964 | Chromodomain Y like. | Histone deacetylase 2. | 0.839 |
| CR201_G0037536 | CBX5 | ENSPPYP00000010840 | ENSPPYP00000005247 | WIZ isoform 3. | CBX5 isoform 2. | 0.733 |
| CR201_G0037536 | CDYL | ENSPPYP00000010840 | ENSPPYP00000018112 | WIZ isoform 3. | Chromodomain Y like. | 0.838 |
