STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4BC4B isoform 2. (1744 aa)    
Predicted Functional Partners:
MASP2
MASP2 isoform 1; Belongs to the peptidase S1 family.
   
 0.990
C4BPA
C4BPA isoform 1.
   
 0.982
MASP1
MASP1 isoform 1.
   
 0.976
C4BPB
Complement component 4 binding protein beta.
   
 0.972
C1S
C1S isoform 1; Belongs to the peptidase S1 family.
   
 0.971
ENSPPYP00000023939
LOW QUALITY PROTEIN: complement C1s subcomponent-like.
   
 0.971
C3
C3 isoform 1.
   
 
0.970
C1QC
Complement C1q C chain.
   
 
 0.962
MBL2
MBL2 isoform 1.
   
 0.950
CD46
Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).
    
 0.940
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.