STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP21A2CYP21A2 isoform 1; Belongs to the cytochrome P450 family. (495 aa)    
Predicted Functional Partners:
HSD3B1
HSD3B1 isoform 1; Belongs to the 3-beta-HSD family.
   
 0.962
CYP11B2
Cytochrome P450 11B2, mitochondrial isoform X1.
  
0.956
CYP11B1
CYP11B2 isoform 1.
  
0.949
CR201_G0028793
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
0.948
SRD5A1
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).
     
 0.939
CYP17A1
CYP17A1 isoform 1; Belongs to the cytochrome P450 family.
  
 
0.938
SRD5A2
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).
     
 0.938
CYP7B1
Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.
  
  
0.933
HSD11B1L
HSD11B1L isoform 21.
   
 
 0.919
AKR1C2
Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family.
   
 
 0.911
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.