ATF6B protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	ATF6	ENSPPYP00000013213	ENSPPYP00000000688	ATF4 isoform 1.	Activating transcription factor 6.	0.656
ATF4	ATF6B	ENSPPYP00000013213	ENSPPYP00000018428	ATF4 isoform 1.	ATF6B isoform 2.	0.950
ATF4	CREB3	ENSPPYP00000013213	ENSPPYP00000021385	ATF4 isoform 1.	cAMP responsive element binding protein 3.	0.909
ATF4	CREB3L1	ENSPPYP00000013213	ENSPPYP00000003817	ATF4 isoform 1.	CREB3L1 isoform 1.	0.907
ATF4	CREB3L2	ENSPPYP00000013213	ENSPPYP00000020238	ATF4 isoform 1.	Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...]	0.906
ATF4	CREB3L3	ENSPPYP00000013213	ENSPPYP00000010536	ATF4 isoform 1.	CREB3L3 isoform 1.	0.912
ATF4	DDIT3	ENSPPYP00000013213	ENSPPYP00000005345	ATF4 isoform 1.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.994
ATF4	HSPA5	ENSPPYP00000013213	ENSPPYP00000021973	ATF4 isoform 1.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.915
ATF4	RPS6KA5	ENSPPYP00000013213	ENSPPYP00000006894	ATF4 isoform 1.	Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional act [...]	0.914
ATF6	ATF4	ENSPPYP00000000688	ENSPPYP00000013213	Activating transcription factor 6.	ATF4 isoform 1.	0.656
ATF6	ATF6B	ENSPPYP00000000688	ENSPPYP00000018428	Activating transcription factor 6.	ATF6B isoform 2.	0.956
ATF6	CREB3L1	ENSPPYP00000000688	ENSPPYP00000003817	Activating transcription factor 6.	CREB3L1 isoform 1.	0.460
ATF6	DDIT3	ENSPPYP00000000688	ENSPPYP00000005345	Activating transcription factor 6.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.985
ATF6	HSPA5	ENSPPYP00000000688	ENSPPYP00000021973	Activating transcription factor 6.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.998
ATF6	WFS1	ENSPPYP00000000688	ENSPPYP00000016298	Activating transcription factor 6.	WFS1 isoform 1.	0.934
ATF6B	ATF4	ENSPPYP00000018428	ENSPPYP00000013213	ATF6B isoform 2.	ATF4 isoform 1.	0.950
ATF6B	ATF6	ENSPPYP00000018428	ENSPPYP00000000688	ATF6B isoform 2.	Activating transcription factor 6.	0.956
ATF6B	CREB3	ENSPPYP00000018428	ENSPPYP00000021385	ATF6B isoform 2.	cAMP responsive element binding protein 3.	0.925
ATF6B	CREB3L1	ENSPPYP00000018428	ENSPPYP00000003817	ATF6B isoform 2.	CREB3L1 isoform 1.	0.926
ATF6B	CREB3L2	ENSPPYP00000018428	ENSPPYP00000020238	ATF6B isoform 2.	Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...]	0.926