NOTCH4 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	ENSPPYP00000022269	ENSPPYP00000019254	ENSPPYP00000022269	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.640
DLL1	MAML1	ENSPPYP00000019254	ENSPPYP00000018042	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MAML1 isoform 1.	0.576
DLL1	MAML2	ENSPPYP00000019254	ENSPPYP00000004339	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MAML2 isoform 2.	0.561
DLL1	NOTCH1	ENSPPYP00000019254	ENSPPYP00000022176	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH1 isoform 1.	0.925
DLL1	NOTCH3	ENSPPYP00000019254	ENSPPYP00000010835	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH3 isoform 1.	0.996
DLL1	NOTCH4	ENSPPYP00000019254	ENSPPYP00000018437	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH4 isoform 1.	0.849
DLL1	RBPJ	ENSPPYP00000019254	ENSPPYP00000016373	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]	0.640
ENSPPYP00000007046	ENSPPYP00000022269	ENSPPYP00000007046	ENSPPYP00000022269	annotation not available	annotation not available	0.595
ENSPPYP00000007046	JAG1	ENSPPYP00000007046	ENSPPYP00000011973	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.705
ENSPPYP00000007046	MAML1	ENSPPYP00000007046	ENSPPYP00000018042	annotation not available	MAML1 isoform 1.	0.574
ENSPPYP00000007046	MAML2	ENSPPYP00000007046	ENSPPYP00000004339	annotation not available	MAML2 isoform 2.	0.548
ENSPPYP00000007046	NOTCH1	ENSPPYP00000007046	ENSPPYP00000022176	annotation not available	NOTCH1 isoform 1.	0.933
ENSPPYP00000007046	NOTCH3	ENSPPYP00000007046	ENSPPYP00000010835	annotation not available	NOTCH3 isoform 1.	0.977
ENSPPYP00000007046	NOTCH4	ENSPPYP00000007046	ENSPPYP00000018437	annotation not available	NOTCH4 isoform 1.	0.857
ENSPPYP00000007046	RBPJ	ENSPPYP00000007046	ENSPPYP00000016373	annotation not available	Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]	0.595
ENSPPYP00000022269	DLL1	ENSPPYP00000022269	ENSPPYP00000019254	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.640
ENSPPYP00000022269	ENSPPYP00000007046	ENSPPYP00000022269	ENSPPYP00000007046	annotation not available	annotation not available	0.595
ENSPPYP00000022269	JAG1	ENSPPYP00000022269	ENSPPYP00000011973	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.645
ENSPPYP00000022269	MAML1	ENSPPYP00000022269	ENSPPYP00000018042	annotation not available	MAML1 isoform 1.	0.961
ENSPPYP00000022269	MAML2	ENSPPYP00000022269	ENSPPYP00000004339	annotation not available	MAML2 isoform 2.	0.927