SRPK1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0034160	ENSPPYP00000022299	ENSPPYP00000004331	ENSPPYP00000022299	SRSF8 isoform 1.	annotation not available	0.763
CR201_G0034160	SRPK1	ENSPPYP00000004331	ENSPPYP00000018496	SRSF8 isoform 1.	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.952
CR201_G0034160	SRPK2	ENSPPYP00000004331	ENSPPYP00000020054	SRSF8 isoform 1.	SRPK2 isoform 7.	0.852
CR201_G0034160	SRSF1	ENSPPYP00000004331	ENSPPYP00000024624	SRSF8 isoform 1.	Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...]	0.951
CR201_G0034160	SRSF2	ENSPPYP00000004331	ENSPPYP00000009735	SRSF8 isoform 1.	Serine and arginine rich splicing factor 2.	0.914
CR201_G0034160	SRSF3	ENSPPYP00000004331	ENSPPYP00000018510	SRSF8 isoform 1.	SRSF3 isoform 5.	0.960
CR201_G0034160	SRSF4	ENSPPYP00000004331	ENSPPYP00000001880	SRSF8 isoform 1.	SRSF4 isoform 3.	0.900
CR201_G0034160	SRSF5	ENSPPYP00000004331	ENSPPYP00000006761	SRSF8 isoform 1.	Serine and arginine rich splicing factor 5.	0.899
CR201_G0034160	SRSF6	ENSPPYP00000004331	ENSPPYP00000012307	SRSF8 isoform 1.	SRSF6 isoform 1.	0.833
CR201_G0034160	SRSF9	ENSPPYP00000004331	ENSPPYP00000005733	SRSF8 isoform 1.	SRSF9 isoform 1.	0.763
ENSPPYP00000022299	CR201_G0034160	ENSPPYP00000022299	ENSPPYP00000004331	annotation not available	SRSF8 isoform 1.	0.763
ENSPPYP00000022299	SRPK1	ENSPPYP00000022299	ENSPPYP00000018496	annotation not available	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.939
ENSPPYP00000022299	SRPK2	ENSPPYP00000022299	ENSPPYP00000020054	annotation not available	SRPK2 isoform 7.	0.421
ENSPPYP00000022299	SRSF1	ENSPPYP00000022299	ENSPPYP00000024624	annotation not available	Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...]	0.935
ENSPPYP00000022299	SRSF2	ENSPPYP00000022299	ENSPPYP00000009735	annotation not available	Serine and arginine rich splicing factor 2.	0.763
ENSPPYP00000022299	SRSF3	ENSPPYP00000022299	ENSPPYP00000018510	annotation not available	SRSF3 isoform 5.	0.856
ENSPPYP00000022299	SRSF4	ENSPPYP00000022299	ENSPPYP00000001880	annotation not available	SRSF4 isoform 3.	0.754
ENSPPYP00000022299	SRSF5	ENSPPYP00000022299	ENSPPYP00000006761	annotation not available	Serine and arginine rich splicing factor 5.	0.809
ENSPPYP00000022299	SRSF6	ENSPPYP00000022299	ENSPPYP00000012307	annotation not available	SRSF6 isoform 1.	0.885
SRPK1	CR201_G0034160	ENSPPYP00000018496	ENSPPYP00000004331	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	SRSF8 isoform 1.	0.952