| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATF2 | DUSP1 | ENSPPYP00000014461 | ENSPPYP00000017960 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.424 |
| ATF2 | MAPK13 | ENSPPYP00000014461 | ENSPPYP00000018501 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Mitogen-activated protein kinase. | 0.974 |
| ATF2 | MAPK14 | ENSPPYP00000014461 | ENSPPYP00000018500 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Mitogen-activated protein kinase. | 0.996 |
| ATF2 | RPS6KA4 | ENSPPYP00000014461 | ENSPPYP00000024357 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Ribosomal protein S6 kinase. | 0.776 |
| ATF2 | RPS6KA5 | ENSPPYP00000014461 | ENSPPYP00000006894 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional act [...] | 0.942 |
| ATF2 | TP53 | ENSPPYP00000014461 | ENSPPYP00000008923 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.414 |
| DUSP1 | ATF2 | ENSPPYP00000017960 | ENSPPYP00000014461 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.424 |
| DUSP1 | MAPK13 | ENSPPYP00000017960 | ENSPPYP00000018501 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase. | 0.944 |
| DUSP1 | MAPK14 | ENSPPYP00000017960 | ENSPPYP00000018500 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase. | 0.992 |
| MAP2K3 | MAP2K6 | ENSPPYP00000009080 | ENSPPYP00000009634 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | 0.997 |
| MAP2K3 | MAPK13 | ENSPPYP00000009080 | ENSPPYP00000018501 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.975 |
| MAP2K3 | MAPK14 | ENSPPYP00000009080 | ENSPPYP00000018500 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.998 |
| MAP2K3 | MAPKAPK2 | ENSPPYP00000009080 | ENSPPYP00000000301 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.684 |
| MAP2K3 | MAPKAPK3 | ENSPPYP00000009080 | ENSPPYP00000015481 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. | 0.585 |
| MAP2K6 | MAP2K3 | ENSPPYP00000009634 | ENSPPYP00000009080 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | 0.997 |
| MAP2K6 | MAPK13 | ENSPPYP00000009634 | ENSPPYP00000018501 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.977 |
| MAP2K6 | MAPK14 | ENSPPYP00000009634 | ENSPPYP00000018500 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.997 |
| MAP2K6 | MAPKAPK2 | ENSPPYP00000009634 | ENSPPYP00000000301 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.967 |
| MAP2K6 | MAPKAPK3 | ENSPPYP00000009634 | ENSPPYP00000015481 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. | 0.582 |
| MAPK13 | ATF2 | ENSPPYP00000018501 | ENSPPYP00000014461 | Mitogen-activated protein kinase. | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.974 |
