PTK7 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA1C	PTK7	ENSPPYP00000004726	ENSPPYP00000018604	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.754
CCK	CCKAR	ENSPPYP00000015640	ENSPPYP00000016374	Cholecystokinin.	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.	0.998
CCK	CCKBR	ENSPPYP00000015640	ENSPPYP00000004068	Cholecystokinin.	CCKBR isoform 1; Belongs to the G-protein coupled receptor 1 family.	0.984
CCK	PTK7	ENSPPYP00000015640	ENSPPYP00000018604	Cholecystokinin.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.622
CCKAR	CCK	ENSPPYP00000016374	ENSPPYP00000015640	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.	Cholecystokinin.	0.998
CCKAR	PTK7	ENSPPYP00000016374	ENSPPYP00000018604	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.666
CCKBR	CCK	ENSPPYP00000004068	ENSPPYP00000015640	CCKBR isoform 1; Belongs to the G-protein coupled receptor 1 family.	Cholecystokinin.	0.984
CCKBR	PTK7	ENSPPYP00000004068	ENSPPYP00000018604	CCKBR isoform 1; Belongs to the G-protein coupled receptor 1 family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.644
ERBB2	PTK7	ENSPPYP00000009527	ENSPPYP00000018604	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.741
FZD3	FZD6	ENSPPYP00000020708	ENSPPYP00000021096	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	0.459
FZD3	PTK7	ENSPPYP00000020708	ENSPPYP00000018604	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.630
FZD3	VANGL1	ENSPPYP00000020708	ENSPPYP00000001153	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Vang-like protein.	0.624
FZD3	VANGL2	ENSPPYP00000020708	ENSPPYP00000000733	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Vang-like protein.	0.727
FZD6	FZD3	ENSPPYP00000021096	ENSPPYP00000020708	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.459
FZD6	PTK7	ENSPPYP00000021096	ENSPPYP00000018604	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.660
FZD6	VANGL1	ENSPPYP00000021096	ENSPPYP00000001153	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Vang-like protein.	0.787
FZD6	VANGL2	ENSPPYP00000021096	ENSPPYP00000000733	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Vang-like protein.	0.799
NGFR	PTK7	ENSPPYP00000010010	ENSPPYP00000018604	NGFR isoform 1.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.641
PTK7	CACNA1C	ENSPPYP00000018604	ENSPPYP00000004726	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.754
PTK7	CCK	ENSPPYP00000018604	ENSPPYP00000015640	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cholecystokinin.	0.622