STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSP90AB1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa)    
Predicted Functional Partners:
AIP
Peptidylprolyl isomerase.
    
 0.998
AHR
T0067486 isoform 1.
    
 0.998
CDC37
CDC37 isoform 2.
   
 0.995
STIP1
STIP1 isoform 2.
   
 0.993
STUB1
STIP1 homology and U-box containing protein 1.
    
 0.991
DKFZp468G2216
AR isoform 8.
   
 0.989
HSPA4
Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.
   
 0.986
CDK4
CDK4 isoform 2; Belongs to the protein kinase superfamily.
   
 0.981
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1.
  
 0.981
AHSA1
AHSA1 isoform 1.
   
 
 0.980
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.