RUNX2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0011709	EP300	ENSPPYP00000014954	ENSPPYP00000013236	HDAC7 isoform 6.	EP300 isoform 1.	0.632
CR201_G0011709	RUNX2	ENSPPYP00000014954	ENSPPYP00000018641	HDAC7 isoform 6.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.904
CR201_G0011709	RUNX3	ENSPPYP00000014954	ENSPPYP00000001981	HDAC7 isoform 6.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.633
CR201_G0015086	EP300	ENSPPYP00000008404	ENSPPYP00000013236	CBFB isoform 2.	EP300 isoform 1.	0.529
CR201_G0015086	RUNX2	ENSPPYP00000008404	ENSPPYP00000018641	CBFB isoform 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.989
CR201_G0015086	RUNX3	ENSPPYP00000008404	ENSPPYP00000001981	CBFB isoform 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.990
CR201_G0015086	YAP1	ENSPPYP00000008404	ENSPPYP00000004354	CBFB isoform 2.	YAP1 isoform 2.	0.518
EP300	CR201_G0011709	ENSPPYP00000013236	ENSPPYP00000014954	EP300 isoform 1.	HDAC7 isoform 6.	0.632
EP300	CR201_G0015086	ENSPPYP00000013236	ENSPPYP00000008404	EP300 isoform 1.	CBFB isoform 2.	0.529
EP300	FOS	ENSPPYP00000013236	ENSPPYP00000006826	EP300 isoform 1.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.904
EP300	PRKACB	ENSPPYP00000013236	ENSPPYP00000001400	EP300 isoform 1.	PRKACB isoform 9; Belongs to the protein kinase superfamily.	0.928
EP300	PRKACG	ENSPPYP00000013236	ENSPPYP00000021585	EP300 isoform 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.926
EP300	RUNX2	ENSPPYP00000013236	ENSPPYP00000018641	EP300 isoform 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.909
EP300	RUNX3	ENSPPYP00000013236	ENSPPYP00000001981	EP300 isoform 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.794
EP300	SOX9	ENSPPYP00000013236	ENSPPYP00000009638	EP300 isoform 1.	SRY-box transcription factor 9.	0.836
EP300	YAP1	ENSPPYP00000013236	ENSPPYP00000004354	EP300 isoform 1.	YAP1 isoform 2.	0.719
FOS	EP300	ENSPPYP00000006826	ENSPPYP00000013236	Fos proto-oncogene, AP-1 transcription factor subunit.	EP300 isoform 1.	0.904
FOS	PRKACB	ENSPPYP00000006826	ENSPPYP00000001400	Fos proto-oncogene, AP-1 transcription factor subunit.	PRKACB isoform 9; Belongs to the protein kinase superfamily.	0.937
FOS	PRKACG	ENSPPYP00000006826	ENSPPYP00000021585	Fos proto-oncogene, AP-1 transcription factor subunit.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.936
FOS	RUNX2	ENSPPYP00000006826	ENSPPYP00000018641	Fos proto-oncogene, AP-1 transcription factor subunit.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.965