node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | DLAT | ENSPPYP00000023609 | ENSPPYP00000004435 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.984 |
ACLY | DLST | ENSPPYP00000023609 | ENSPPYP00000006812 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Dihydrolipoamide S-succinyltransferase. | 0.763 |
ACLY | ENSPPYP00000024659 | ENSPPYP00000023609 | ENSPPYP00000024659 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.763 |
ACLY | MDH1 | ENSPPYP00000023609 | ENSPPYP00000013797 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malate dehydrogenase. | 0.958 |
ACLY | MMUT | ENSPPYP00000023609 | ENSPPYP00000018666 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family. | 0.841 |
ACLY | SUCLG1 | ENSPPYP00000023609 | ENSPPYP00000013652 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.982 |
ACSF3 | MCEE | ENSPPYP00000008636 | ENSPPYP00000013730 | Acyl-CoA synthetase family member 3. | MCEE isoform 2. | 0.927 |
ACSF3 | MMUT | ENSPPYP00000008636 | ENSPPYP00000018666 | Acyl-CoA synthetase family member 3. | Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family. | 0.905 |
DLAT | ACLY | ENSPPYP00000004435 | ENSPPYP00000023609 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.984 |
DLAT | DLST | ENSPPYP00000004435 | ENSPPYP00000006812 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide S-succinyltransferase. | 0.843 |
DLAT | ENSPPYP00000024659 | ENSPPYP00000004435 | ENSPPYP00000024659 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.844 |
DLAT | MMUT | ENSPPYP00000004435 | ENSPPYP00000018666 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family. | 0.815 |
DLAT | SUCLA2 | ENSPPYP00000004435 | ENSPPYP00000006097 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.960 |
DLAT | SUCLG1 | ENSPPYP00000004435 | ENSPPYP00000013652 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.977 |
DLST | ACLY | ENSPPYP00000006812 | ENSPPYP00000023609 | Dihydrolipoamide S-succinyltransferase. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.763 |
DLST | DLAT | ENSPPYP00000006812 | ENSPPYP00000004435 | Dihydrolipoamide S-succinyltransferase. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.843 |
DLST | ENSPPYP00000024659 | ENSPPYP00000006812 | ENSPPYP00000024659 | Dihydrolipoamide S-succinyltransferase. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.900 |
DLST | MDH1 | ENSPPYP00000006812 | ENSPPYP00000013797 | Dihydrolipoamide S-succinyltransferase. | Malate dehydrogenase. | 0.402 |
DLST | MMUT | ENSPPYP00000006812 | ENSPPYP00000018666 | Dihydrolipoamide S-succinyltransferase. | Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family. | 0.815 |
DLST | SUCLA2 | ENSPPYP00000006812 | ENSPPYP00000006097 | Dihydrolipoamide S-succinyltransferase. | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.978 |