MCHR2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNA11	GNA14	ENSPPYP00000010507	ENSPPYP00000021632	GNA11 isoform 1.	G protein subunit alpha 14.	0.993
GNA11	GNAQ	ENSPPYP00000010507	ENSPPYP00000021633	GNA11 isoform 1.	G protein subunit alpha q.	0.997
GNA11	GNB1	ENSPPYP00000010507	ENSPPYP00000002307	GNA11 isoform 1.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.897
GNA11	GNB2	ENSPPYP00000010507	ENSPPYP00000019528	GNA11 isoform 1.	GNB2 isoform 1.	0.776
GNA11	GNB3	ENSPPYP00000010507	ENSPPYP00000004790	GNA11 isoform 1.	G protein subunit beta 3.	0.798
GNA11	GNB5	ENSPPYP00000010507	ENSPPYP00000007348	GNA11 isoform 1.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.676
GNA11	GNG3	ENSPPYP00000010507	ENSPPYP00000003639	GNA11 isoform 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.711
GNA11	GNG4	ENSPPYP00000010507	ENSPPYP00000000094	GNA11 isoform 1.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.829
GNA11	MCHR2	ENSPPYP00000010507	ENSPPYP00000018881	GNA11 isoform 1.	Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.936
GNA14	GNA11	ENSPPYP00000021632	ENSPPYP00000010507	G protein subunit alpha 14.	GNA11 isoform 1.	0.993
GNA14	GNAQ	ENSPPYP00000021632	ENSPPYP00000021633	G protein subunit alpha 14.	G protein subunit alpha q.	0.992
GNA14	GNB1	ENSPPYP00000021632	ENSPPYP00000002307	G protein subunit alpha 14.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.828
GNA14	GNB2	ENSPPYP00000021632	ENSPPYP00000019528	G protein subunit alpha 14.	GNB2 isoform 1.	0.776
GNA14	GNB3	ENSPPYP00000021632	ENSPPYP00000004790	G protein subunit alpha 14.	G protein subunit beta 3.	0.798
GNA14	GNB5	ENSPPYP00000021632	ENSPPYP00000007348	G protein subunit alpha 14.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.676
GNA14	GNG3	ENSPPYP00000021632	ENSPPYP00000003639	G protein subunit alpha 14.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.699
GNA14	GNG4	ENSPPYP00000021632	ENSPPYP00000000094	G protein subunit alpha 14.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.829
GNA14	MCHR2	ENSPPYP00000021632	ENSPPYP00000018881	G protein subunit alpha 14.	Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.937
GNAQ	GNA11	ENSPPYP00000021633	ENSPPYP00000010507	G protein subunit alpha q.	GNA11 isoform 1.	0.997
GNAQ	GNA14	ENSPPYP00000021633	ENSPPYP00000021632	G protein subunit alpha q.	G protein subunit alpha 14.	0.992