HSF2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPPYP00000005659	HSF1	ENSPPYP00000005659	ENSPPYP00000021274	annotation not available	HSF1 isoform 2.	0.875
ENSPPYP00000005659	HSF2	ENSPPYP00000005659	ENSPPYP00000019006	annotation not available	Heat shock transcription factor 2.	0.610
ENSPPYP00000005659	HSF4	ENSPPYP00000005659	ENSPPYP00000008407	annotation not available	HSF4 isoform 10.	0.602
ENSPPYP00000005659	HSPA2	ENSPPYP00000005659	ENSPPYP00000006709	annotation not available	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.967
ENSPPYP00000005659	HSPA4	ENSPPYP00000005659	ENSPPYP00000017643	annotation not available	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.942
ENSPPYP00000005659	HSPBP1	ENSPPYP00000005659	ENSPPYP00000011668	annotation not available	HSPBP1 isoform 1.	0.859
ENSPPYP00000005659	PTGES3	ENSPPYP00000005659	ENSPPYP00000005319	annotation not available	Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.	0.584
ENSPPYP00000016754	HSF1	ENSPPYP00000016754	ENSPPYP00000021274	annotation not available	HSF1 isoform 2.	0.855
ENSPPYP00000016754	HSF2	ENSPPYP00000016754	ENSPPYP00000019006	annotation not available	Heat shock transcription factor 2.	0.624
ENSPPYP00000016754	HSF4	ENSPPYP00000016754	ENSPPYP00000008407	annotation not available	HSF4 isoform 10.	0.679
ENSPPYP00000016754	HSPA4	ENSPPYP00000016754	ENSPPYP00000017643	annotation not available	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.417
HSBP1	HSF1	ENSPPYP00000008675	ENSPPYP00000021274	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	HSF1 isoform 2.	0.855
HSBP1	HSF2	ENSPPYP00000008675	ENSPPYP00000019006	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	Heat shock transcription factor 2.	0.624
HSBP1	HSF4	ENSPPYP00000008675	ENSPPYP00000008407	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	HSF4 isoform 10.	0.679
HSBP1	HSPA4	ENSPPYP00000008675	ENSPPYP00000017643	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.417
HSF1	ENSPPYP00000005659	ENSPPYP00000021274	ENSPPYP00000005659	HSF1 isoform 2.	annotation not available	0.875
HSF1	ENSPPYP00000016754	ENSPPYP00000021274	ENSPPYP00000016754	HSF1 isoform 2.	annotation not available	0.855
HSF1	HSBP1	ENSPPYP00000021274	ENSPPYP00000008675	HSF1 isoform 2.	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	0.855
HSF1	HSF2	ENSPPYP00000021274	ENSPPYP00000019006	HSF1 isoform 2.	Heat shock transcription factor 2.	0.916
HSF1	HSF4	ENSPPYP00000021274	ENSPPYP00000008407	HSF1 isoform 2.	HSF4 isoform 10.	0.703