LATS1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJUBA	LATS1	ENSPPYP00000006424	ENSPPYP00000019136	LIM domain-containing protein ajuba isoform X1.	Large tumor suppressor kinase 1.	0.961
AJUBA	LATS2	ENSPPYP00000006424	ENSPPYP00000005920	LIM domain-containing protein ajuba isoform X1.	Non-specific serine/threonine protein kinase.	0.981
AJUBA	LIMD1	ENSPPYP00000006424	ENSPPYP00000015597	LIM domain-containing protein ajuba isoform X1.	LIM domains containing 1.	0.953
AJUBA	SAV1	ENSPPYP00000006424	ENSPPYP00000006597	LIM domain-containing protein ajuba isoform X1.	Salvador family WW domain containing protein 1.	0.932
LATS1	AJUBA	ENSPPYP00000019136	ENSPPYP00000006424	Large tumor suppressor kinase 1.	LIM domain-containing protein ajuba isoform X1.	0.961
LATS1	LATS2	ENSPPYP00000019136	ENSPPYP00000005920	Large tumor suppressor kinase 1.	Non-specific serine/threonine protein kinase.	0.998
LATS1	LIMD1	ENSPPYP00000019136	ENSPPYP00000015597	Large tumor suppressor kinase 1.	LIM domains containing 1.	0.974
LATS1	MOB1A	ENSPPYP00000019136	ENSPPYP00000013698	Large tumor suppressor kinase 1.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.991
LATS1	MOB1B	ENSPPYP00000019136	ENSPPYP00000016542	Large tumor suppressor kinase 1.	MOB kinase activator 1B.	0.997
LATS1	SAV1	ENSPPYP00000019136	ENSPPYP00000006597	Large tumor suppressor kinase 1.	Salvador family WW domain containing protein 1.	0.983
LATS1	STK3	ENSPPYP00000019136	ENSPPYP00000021064	Large tumor suppressor kinase 1.	STK3 isoform 3.	0.996
LATS1	WWC1	ENSPPYP00000019136	ENSPPYP00000017932	Large tumor suppressor kinase 1.	WWC1 isoform 1.	0.973
LATS1	WWTR1	ENSPPYP00000019136	ENSPPYP00000015879	Large tumor suppressor kinase 1.	WW domain containing transcription regulator 1.	0.998
LATS1	YAP1	ENSPPYP00000019136	ENSPPYP00000004354	Large tumor suppressor kinase 1.	YAP1 isoform 2.	0.998
LATS2	AJUBA	ENSPPYP00000005920	ENSPPYP00000006424	Non-specific serine/threonine protein kinase.	LIM domain-containing protein ajuba isoform X1.	0.981
LATS2	LATS1	ENSPPYP00000005920	ENSPPYP00000019136	Non-specific serine/threonine protein kinase.	Large tumor suppressor kinase 1.	0.998
LATS2	LIMD1	ENSPPYP00000005920	ENSPPYP00000015597	Non-specific serine/threonine protein kinase.	LIM domains containing 1.	0.957
LATS2	MOB1A	ENSPPYP00000005920	ENSPPYP00000013698	Non-specific serine/threonine protein kinase.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.984
LATS2	MOB1B	ENSPPYP00000005920	ENSPPYP00000016542	Non-specific serine/threonine protein kinase.	MOB kinase activator 1B.	0.996
LATS2	SAV1	ENSPPYP00000005920	ENSPPYP00000006597	Non-specific serine/threonine protein kinase.	Salvador family WW domain containing protein 1.	0.984