ESR1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	ESR1	ENSPPYP00000007036	ENSPPYP00000019159	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.990
AKT1	ESR2	ENSPPYP00000007036	ENSPPYP00000006703	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ESR2 isoform 12.	0.966
AKT1	FOS	ENSPPYP00000007036	ENSPPYP00000006826	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.525
AKT1	JUN	ENSPPYP00000007036	ENSPPYP00000001511	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	JUN isoform 1; Belongs to the bZIP family.	0.964
AKT1	PGR	ENSPPYP00000007036	ENSPPYP00000004346	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PGR isoform 1.	0.487
AKT1	SRC	ENSPPYP00000007036	ENSPPYP00000012270	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.916
ESR1	AKT1	ENSPPYP00000019159	ENSPPYP00000007036	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.990
ESR1	ESR2	ENSPPYP00000019159	ENSPPYP00000006703	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	ESR2 isoform 12.	0.999
ESR1	FOS	ENSPPYP00000019159	ENSPPYP00000006826	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.988
ESR1	JUN	ENSPPYP00000019159	ENSPPYP00000001511	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	JUN isoform 1; Belongs to the bZIP family.	0.990
ESR1	MED1	ENSPPYP00000019159	ENSPPYP00000009539	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	0.996
ESR1	NCOA2	ENSPPYP00000019159	ENSPPYP00000024008	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.993
ESR1	NCOA3	ENSPPYP00000019159	ENSPPYP00000012407	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.999
ESR1	PGR	ENSPPYP00000019159	ENSPPYP00000004346	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	PGR isoform 1.	0.987
ESR1	SP1	ENSPPYP00000019159	ENSPPYP00000005222	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.996
ESR1	SRC	ENSPPYP00000019159	ENSPPYP00000012270	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.997
ESR2	AKT1	ENSPPYP00000006703	ENSPPYP00000007036	ESR2 isoform 12.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.966
ESR2	ESR1	ENSPPYP00000006703	ENSPPYP00000019159	ESR2 isoform 12.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.999
ESR2	FOS	ENSPPYP00000006703	ENSPPYP00000006826	ESR2 isoform 12.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.969
ESR2	JUN	ENSPPYP00000006703	ENSPPYP00000001511	ESR2 isoform 12.	JUN isoform 1; Belongs to the bZIP family.	0.971