| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACADM | ACAT2 | ENSPPYP00000001431 | ENSPPYP00000019199 | Acyl-CoA dehydrogenase medium chain. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.959 |
| ACADM | ACOX1 | ENSPPYP00000001431 | ENSPPYP00000009707 | Acyl-CoA dehydrogenase medium chain. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.955 |
| ACADM | ACSS1 | ENSPPYP00000001431 | ENSPPYP00000012045 | Acyl-CoA dehydrogenase medium chain. | Acetyl-coenzyme A synthetase. | 0.418 |
| ACADM | CS | ENSPPYP00000001431 | ENSPPYP00000005303 | Acyl-CoA dehydrogenase medium chain. | Citrate synthase, mitochondrial isoform X1. | 0.661 |
| ACADM | EHHADH | ENSPPYP00000001431 | ENSPPYP00000016064 | Acyl-CoA dehydrogenase medium chain. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.971 |
| ACADM | HADH | ENSPPYP00000001431 | ENSPPYP00000016738 | Acyl-CoA dehydrogenase medium chain. | Hydroxyacyl-CoA dehydrogenase. | 0.924 |
| ACADM | HADHA | ENSPPYP00000001431 | ENSPPYP00000014051 | Acyl-CoA dehydrogenase medium chain. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.988 |
| ACADM | HMGCS1 | ENSPPYP00000001431 | ENSPPYP00000017251 | Acyl-CoA dehydrogenase medium chain. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.452 |
| ACADM | HMGCS2 | ENSPPYP00000001431 | ENSPPYP00000001119 | Acyl-CoA dehydrogenase medium chain. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.653 |
| ACADM | OXCT1 | ENSPPYP00000001431 | ENSPPYP00000017238 | Acyl-CoA dehydrogenase medium chain. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.510 |
| ACAT2 | ACADM | ENSPPYP00000019199 | ENSPPYP00000001431 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Acyl-CoA dehydrogenase medium chain. | 0.959 |
| ACAT2 | ACOX1 | ENSPPYP00000019199 | ENSPPYP00000009707 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.956 |
| ACAT2 | ACSS1 | ENSPPYP00000019199 | ENSPPYP00000012045 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase. | 0.957 |
| ACAT2 | CS | ENSPPYP00000019199 | ENSPPYP00000005303 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Citrate synthase, mitochondrial isoform X1. | 0.961 |
| ACAT2 | EHHADH | ENSPPYP00000019199 | ENSPPYP00000016064 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.971 |
| ACAT2 | HADH | ENSPPYP00000019199 | ENSPPYP00000016738 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase. | 0.981 |
| ACAT2 | HADHA | ENSPPYP00000019199 | ENSPPYP00000014051 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.970 |
| ACAT2 | HMGCS1 | ENSPPYP00000019199 | ENSPPYP00000017251 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.993 |
| ACAT2 | HMGCS2 | ENSPPYP00000019199 | ENSPPYP00000001119 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.986 |
| ACAT2 | OXCT1 | ENSPPYP00000019199 | ENSPPYP00000017238 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.965 |
