DLL1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DLL1

Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)

Predicted Functional Partners:

NOTCH3

0.998

NOTCH1

0.988

NOTCH4

0.987

DLL4

0.949

NOTCH2

0.926

DLL3

0.925

ENSPPYP00000018739

0.807

CR201_G0041018

0.720

RBPJ

0.715

ENSPPYP00000022269

0.715

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0041018	DLL1	ENSPPYP00000019405	ENSPPYP00000019254	Beta-1,3-N-acetylglucosaminyltransferase.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.720
CR201_G0041018	DLL3	ENSPPYP00000019405	ENSPPYP00000011163	Beta-1,3-N-acetylglucosaminyltransferase.	Delta like canonical Notch ligand 3.	0.693
CR201_G0041018	NOTCH1	ENSPPYP00000019405	ENSPPYP00000022176	Beta-1,3-N-acetylglucosaminyltransferase.	NOTCH1 isoform 1.	0.613
CR201_G0041018	NOTCH3	ENSPPYP00000019405	ENSPPYP00000010835	Beta-1,3-N-acetylglucosaminyltransferase.	NOTCH3 isoform 1.	0.597
DLL1	CR201_G0041018	ENSPPYP00000019254	ENSPPYP00000019405	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.720
DLL1	DLL3	ENSPPYP00000019254	ENSPPYP00000011163	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta like canonical Notch ligand 3.	0.925
DLL1	DLL4	ENSPPYP00000019254	ENSPPYP00000024574	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.949
DLL1	ENSPPYP00000018739	ENSPPYP00000019254	ENSPPYP00000018739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.807
DLL1	ENSPPYP00000022269	ENSPPYP00000019254	ENSPPYP00000022269	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.715
DLL1	NOTCH1	ENSPPYP00000019254	ENSPPYP00000022176	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH1 isoform 1.	0.988
DLL1	NOTCH2	ENSPPYP00000019254	ENSPPYP00000001116	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH2 isoform 2.	0.926
DLL1	NOTCH3	ENSPPYP00000019254	ENSPPYP00000010835	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH3 isoform 1.	0.998
DLL1	NOTCH4	ENSPPYP00000019254	ENSPPYP00000018437	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH4 isoform 1.	0.987
DLL1	RBPJ	ENSPPYP00000019254	ENSPPYP00000016373	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]	0.715
DLL3	CR201_G0041018	ENSPPYP00000011163	ENSPPYP00000019405	Delta like canonical Notch ligand 3.	Beta-1,3-N-acetylglucosaminyltransferase.	0.693
DLL3	DLL1	ENSPPYP00000011163	ENSPPYP00000019254	Delta like canonical Notch ligand 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.925
DLL3	DLL4	ENSPPYP00000011163	ENSPPYP00000024574	Delta like canonical Notch ligand 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.907
DLL3	ENSPPYP00000018739	ENSPPYP00000011163	ENSPPYP00000018739	Delta like canonical Notch ligand 3.	annotation not available	0.660
DLL3	ENSPPYP00000022269	ENSPPYP00000011163	ENSPPYP00000022269	Delta like canonical Notch ligand 3.	annotation not available	0.560
DLL3	NOTCH1	ENSPPYP00000011163	ENSPPYP00000022176	Delta like canonical Notch ligand 3.	NOTCH1 isoform 1.	0.980