Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CR201_G0055889Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)    
Predicted Functional Partners:
B2M
Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
   
 0.781
RPA2
Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...]
   
 0.672
HLA-E
HLA-E isoform 1; Belongs to the MHC class I family.
  
 
0.610
MHC-Poab-C
MHC class I antigen; Belongs to the MHC class I family.
  
 
0.610
Poab-F
MHC class I protein; Belongs to the MHC class I family.
  
 
0.609
HLA-A
Popy Class I histocompatibility antigen, A-1 alpha chain.
  
 
0.609
CR201_G0042422
HLA-G isoform 2; Belongs to the MHC class I family.
  
 
0.609
CR201_G0042434
HLA-A isoform 3; Belongs to the MHC class I family.
  
 
0.609
CR201_G0055693
HLA-B isoform 1; Belongs to the MHC class I family.
  
 
0.608
ENSPPYP00000019353
HLA class I histocompatibility antigen, alpha chain G isoform X1.
   
 
0.604
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.