| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATRX | DAXX | ENSPPYP00000022935 | ENSPPYP00000019339 | ATRX isoform 1. | Death domain associated protein. | 0.997 |
| ATRX | PML | ENSPPYP00000022935 | ENSPPYP00000007521 | ATRX isoform 1. | PML isoform 4. | 0.438 |
| ATRX | TP53 | ENSPPYP00000022935 | ENSPPYP00000008923 | ATRX isoform 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.801 |
| DAXX | ATRX | ENSPPYP00000019339 | ENSPPYP00000022935 | Death domain associated protein. | ATRX isoform 1. | 0.997 |
| DAXX | HIPK2 | ENSPPYP00000019339 | ENSPPYP00000020253 | Death domain associated protein. | HIPK2 isoform 2. | 0.946 |
| DAXX | MAP3K5 | ENSPPYP00000019339 | ENSPPYP00000019077 | Death domain associated protein. | MAP3K5 isoform 1. | 0.995 |
| DAXX | MDM2 | ENSPPYP00000019339 | ENSPPYP00000005415 | Death domain associated protein. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.947 |
| DAXX | PARK7 | ENSPPYP00000019339 | ENSPPYP00000002233 | Death domain associated protein. | PARK7 isoform 1. | 0.942 |
| DAXX | PML | ENSPPYP00000019339 | ENSPPYP00000007521 | Death domain associated protein. | PML isoform 4. | 0.989 |
| DAXX | SPOP | ENSPPYP00000019339 | ENSPPYP00000010012 | Death domain associated protein. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.939 |
| DAXX | TP53 | ENSPPYP00000019339 | ENSPPYP00000008923 | Death domain associated protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.994 |
| DAXX | UBE2I | ENSPPYP00000019339 | ENSPPYP00000007864 | Death domain associated protein. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.952 |
| DAXX | USP7 | ENSPPYP00000019339 | ENSPPYP00000008014 | Death domain associated protein. | USP7 isoform 8; Belongs to the peptidase C19 family. | 0.990 |
| HIPK2 | DAXX | ENSPPYP00000020253 | ENSPPYP00000019339 | HIPK2 isoform 2. | Death domain associated protein. | 0.946 |
| HIPK2 | MDM2 | ENSPPYP00000020253 | ENSPPYP00000005415 | HIPK2 isoform 2. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.853 |
| HIPK2 | PML | ENSPPYP00000020253 | ENSPPYP00000007521 | HIPK2 isoform 2. | PML isoform 4. | 0.819 |
| HIPK2 | SPOP | ENSPPYP00000020253 | ENSPPYP00000010012 | HIPK2 isoform 2. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.611 |
| HIPK2 | TP53 | ENSPPYP00000020253 | ENSPPYP00000008923 | HIPK2 isoform 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.997 |
| HIPK2 | UBE2I | ENSPPYP00000020253 | ENSPPYP00000007864 | HIPK2 isoform 2. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.881 |
| MAP3K5 | DAXX | ENSPPYP00000019077 | ENSPPYP00000019339 | MAP3K5 isoform 1. | Death domain associated protein. | 0.995 |
