GNA12 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF11	ARHGEF12	ENSPPYP00000024021	ENSPPYP00000004552	ARHGEF11 isoform 1.	Rho guanine nucleotide exchange factor 12.	0.938
ARHGEF11	CR201_G0044078	ENSPPYP00000024021	ENSPPYP00000011227	ARHGEF11 isoform 1.	ARHGEF1 isoform 7.	0.447
ARHGEF11	GNA12	ENSPPYP00000024021	ENSPPYP00000019410	ARHGEF11 isoform 1.	GNA12 isoform 1.	0.854
ARHGEF11	GNA13	ENSPPYP00000024021	ENSPPYP00000009607	ARHGEF11 isoform 1.	G protein subunit alpha 13.	0.994
ARHGEF11	GNAI3	ENSPPYP00000024021	ENSPPYP00000001241	ARHGEF11 isoform 1.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.449
ARHGEF12	ARHGEF11	ENSPPYP00000004552	ENSPPYP00000024021	Rho guanine nucleotide exchange factor 12.	ARHGEF11 isoform 1.	0.938
ARHGEF12	GNA12	ENSPPYP00000004552	ENSPPYP00000019410	Rho guanine nucleotide exchange factor 12.	GNA12 isoform 1.	0.981
ARHGEF12	GNA13	ENSPPYP00000004552	ENSPPYP00000009607	Rho guanine nucleotide exchange factor 12.	G protein subunit alpha 13.	0.999
ARHGEF12	GNAI3	ENSPPYP00000004552	ENSPPYP00000001241	Rho guanine nucleotide exchange factor 12.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.449
BTK	GNA12	ENSPPYP00000023007	ENSPPYP00000019410	Tyrosine-protein kinase.	GNA12 isoform 1.	0.836
BTK	GNA13	ENSPPYP00000023007	ENSPPYP00000009607	Tyrosine-protein kinase.	G protein subunit alpha 13.	0.432
CR201_G0044078	ARHGEF11	ENSPPYP00000011227	ENSPPYP00000024021	ARHGEF1 isoform 7.	ARHGEF11 isoform 1.	0.447
CR201_G0044078	GNA12	ENSPPYP00000011227	ENSPPYP00000019410	ARHGEF1 isoform 7.	GNA12 isoform 1.	0.871
CR201_G0044078	GNA13	ENSPPYP00000011227	ENSPPYP00000009607	ARHGEF1 isoform 7.	G protein subunit alpha 13.	0.981
CR201_G0044078	GNAI3	ENSPPYP00000011227	ENSPPYP00000001241	ARHGEF1 isoform 7.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.476
GNA12	ARHGEF11	ENSPPYP00000019410	ENSPPYP00000024021	GNA12 isoform 1.	ARHGEF11 isoform 1.	0.854
GNA12	ARHGEF12	ENSPPYP00000019410	ENSPPYP00000004552	GNA12 isoform 1.	Rho guanine nucleotide exchange factor 12.	0.981
GNA12	BTK	ENSPPYP00000019410	ENSPPYP00000023007	GNA12 isoform 1.	Tyrosine-protein kinase.	0.836
GNA12	CR201_G0044078	ENSPPYP00000019410	ENSPPYP00000011227	GNA12 isoform 1.	ARHGEF1 isoform 7.	0.871
GNA12	GNA13	ENSPPYP00000019410	ENSPPYP00000009607	GNA12 isoform 1.	G protein subunit alpha 13.	0.998