| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCM2 | RHOA | ENSPPYP00000019705 | ENSPPYP00000015522 | CCM2 scaffold protein. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.555 |
| CCM2 | SMURF1 | ENSPPYP00000019705 | ENSPPYP00000019458 | CCM2 scaffold protein. | E3 ubiquitin-protein ligase. | 0.970 |
| CCM2 | SMURF2 | ENSPPYP00000019705 | ENSPPYP00000009604 | CCM2 scaffold protein. | E3 ubiquitin-protein ligase. | 0.946 |
| PTCH1 | PTCH2 | ENSPPYP00000021750 | ENSPPYP00000001647 | PTCH1 isoform 7. | PTCH2 isoform 1. | 0.910 |
| PTCH1 | SMURF1 | ENSPPYP00000021750 | ENSPPYP00000019458 | PTCH1 isoform 7. | E3 ubiquitin-protein ligase. | 0.985 |
| PTCH1 | SMURF2 | ENSPPYP00000021750 | ENSPPYP00000009604 | PTCH1 isoform 7. | E3 ubiquitin-protein ligase. | 0.985 |
| PTCH2 | PTCH1 | ENSPPYP00000001647 | ENSPPYP00000021750 | PTCH2 isoform 1. | PTCH1 isoform 7. | 0.910 |
| PTCH2 | SMURF1 | ENSPPYP00000001647 | ENSPPYP00000019458 | PTCH2 isoform 1. | E3 ubiquitin-protein ligase. | 0.967 |
| PTCH2 | SMURF2 | ENSPPYP00000001647 | ENSPPYP00000009604 | PTCH2 isoform 1. | E3 ubiquitin-protein ligase. | 0.967 |
| RHOA | CCM2 | ENSPPYP00000015522 | ENSPPYP00000019705 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | CCM2 scaffold protein. | 0.555 |
| RHOA | SMURF1 | ENSPPYP00000015522 | ENSPPYP00000019458 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | E3 ubiquitin-protein ligase. | 0.968 |
| RHOA | SMURF2 | ENSPPYP00000015522 | ENSPPYP00000009604 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | E3 ubiquitin-protein ligase. | 0.866 |
| RHOA | TGFBR1 | ENSPPYP00000015522 | ENSPPYP00000021783 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.664 |
| RHOA | TGFBR2 | ENSPPYP00000015522 | ENSPPYP00000015718 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.583 |
| SMAD5 | SMAD6 | ENSPPYP00000017676 | ENSPPYP00000007463 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | Mothers against decapentaplegic homolog. | 0.968 |
| SMAD5 | SMAD7 | ENSPPYP00000017676 | ENSPPYP00000010278 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | Mothers against decapentaplegic homolog. | 0.967 |
| SMAD5 | SMURF1 | ENSPPYP00000017676 | ENSPPYP00000019458 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | E3 ubiquitin-protein ligase. | 0.969 |
| SMAD5 | SMURF2 | ENSPPYP00000017676 | ENSPPYP00000009604 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | E3 ubiquitin-protein ligase. | 0.879 |
| SMAD5 | TGFBR1 | ENSPPYP00000017676 | ENSPPYP00000021783 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.674 |
| SMAD5 | TGFBR2 | ENSPPYP00000017676 | ENSPPYP00000015718 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.591 |
