GNB2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALCR	GNAI3	ENSPPYP00000019965	ENSPPYP00000001241	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.903
CALCR	GNAO1	ENSPPYP00000019965	ENSPPYP00000008317	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	GNAO1 isoform 1.	0.904
CALCR	GNAS	ENSPPYP00000019965	ENSPPYP00000012485	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	GNAS isoform 2.	0.933
CALCR	GNB1	ENSPPYP00000019965	ENSPPYP00000002307	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.983
CALCR	GNB2	ENSPPYP00000019965	ENSPPYP00000019528	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	GNB2 isoform 1.	0.977
CALCR	GNG13	ENSPPYP00000019965	ENSPPYP00000007853	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	GNG13 isoform 1.	0.936
CALCR	GNG3	ENSPPYP00000019965	ENSPPYP00000003639	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.940
DRD2	GNAI3	ENSPPYP00000004451	ENSPPYP00000001241	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.973
DRD2	GNAO1	ENSPPYP00000004451	ENSPPYP00000008317	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	GNAO1 isoform 1.	0.964
DRD2	GNAS	ENSPPYP00000004451	ENSPPYP00000012485	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	GNAS isoform 2.	0.522
DRD2	GNB1	ENSPPYP00000004451	ENSPPYP00000002307	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.981
DRD2	GNB2	ENSPPYP00000004451	ENSPPYP00000019528	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	GNB2 isoform 1.	0.973
DRD2	GNG13	ENSPPYP00000004451	ENSPPYP00000007853	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	GNG13 isoform 1.	0.929
DRD2	GNG3	ENSPPYP00000004451	ENSPPYP00000003639	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.934
GNAI3	CALCR	ENSPPYP00000001241	ENSPPYP00000019965	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family.	0.903
GNAI3	DRD2	ENSPPYP00000001241	ENSPPYP00000004451	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.973
GNAI3	GNAO1	ENSPPYP00000001241	ENSPPYP00000008317	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	GNAO1 isoform 1.	0.980
GNAI3	GNAS	ENSPPYP00000001241	ENSPPYP00000012485	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	GNAS isoform 2.	0.762
GNAI3	GNB1	ENSPPYP00000001241	ENSPPYP00000002307	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.991
GNAI3	GNB2	ENSPPYP00000001241	ENSPPYP00000019528	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	GNB2 isoform 1.	0.987