RHBDD2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RHBDD2

Rhomboid domain containing 2. (364 aa)

Predicted Functional Partners:

RHBDF1

0.457

RHBDD1

0.457

SPATA5L1

0.427

SPATA5

0.427

VCP

0.427

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RHBDD1	RHBDD2	ENSPPYP00000014790	ENSPPYP00000019590	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	Rhomboid domain containing 2.	0.457
RHBDD1	SPATA5	ENSPPYP00000014790	ENSPPYP00000016811	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	SPATA5 isoform 1.	0.540
RHBDD1	SPATA5L1	ENSPPYP00000014790	ENSPPYP00000007302	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	SPATA5L1 isoform 1.	0.540
RHBDD1	VCP	ENSPPYP00000014790	ENSPPYP00000021408	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	Transitional endoplasmic reticulum ATPase isoform X1.	0.914
RHBDD2	RHBDD1	ENSPPYP00000019590	ENSPPYP00000014790	Rhomboid domain containing 2.	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	0.457
RHBDD2	RHBDF1	ENSPPYP00000019590	ENSPPYP00000007807	Rhomboid domain containing 2.	Rhomboid 5 homolog 1.	0.457
RHBDD2	SPATA5	ENSPPYP00000019590	ENSPPYP00000016811	Rhomboid domain containing 2.	SPATA5 isoform 1.	0.427
RHBDD2	SPATA5L1	ENSPPYP00000019590	ENSPPYP00000007302	Rhomboid domain containing 2.	SPATA5L1 isoform 1.	0.427
RHBDD2	VCP	ENSPPYP00000019590	ENSPPYP00000021408	Rhomboid domain containing 2.	Transitional endoplasmic reticulum ATPase isoform X1.	0.427
RHBDF1	RHBDD2	ENSPPYP00000007807	ENSPPYP00000019590	Rhomboid 5 homolog 1.	Rhomboid domain containing 2.	0.457
SPATA5	RHBDD1	ENSPPYP00000016811	ENSPPYP00000014790	SPATA5 isoform 1.	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	0.540
SPATA5	RHBDD2	ENSPPYP00000016811	ENSPPYP00000019590	SPATA5 isoform 1.	Rhomboid domain containing 2.	0.427
SPATA5	SPATA5L1	ENSPPYP00000016811	ENSPPYP00000007302	SPATA5 isoform 1.	SPATA5L1 isoform 1.	0.832
SPATA5L1	RHBDD1	ENSPPYP00000007302	ENSPPYP00000014790	SPATA5L1 isoform 1.	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	0.540
SPATA5L1	RHBDD2	ENSPPYP00000007302	ENSPPYP00000019590	SPATA5L1 isoform 1.	Rhomboid domain containing 2.	0.427
SPATA5L1	SPATA5	ENSPPYP00000007302	ENSPPYP00000016811	SPATA5L1 isoform 1.	SPATA5 isoform 1.	0.832
VCP	RHBDD1	ENSPPYP00000021408	ENSPPYP00000014790	Transitional endoplasmic reticulum ATPase isoform X1.	Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...]	0.914
VCP	RHBDD2	ENSPPYP00000021408	ENSPPYP00000019590	Transitional endoplasmic reticulum ATPase isoform X1.	Rhomboid domain containing 2.	0.427