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STX1A protein (Pongo abelii) - STRING interaction network
"STX1A" - Syntaxin-1A in Pongo abelii
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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STX1ASyntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis. Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of. exocytosis acrosomal reaction in sperm; Belongs to the syntaxin family (259 aa)    
Predicted Functional Partners:
SNAP25
Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (206 aa)
     
  0.999
VAMP2
Vesicle-associated membrane protein 2 (synaptobrevin 2) (116 aa)
     
  0.995
STXBP1
Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity) (581 aa)
     
  0.995
SYT1
Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (377 aa)
     
 
  0.992
SNAP23
Pongo abelii synaptosomal-associated protein, 23kDa (SNAP23), mRNA; Belongs to the SNAP-25 family (211 aa)
     
  0.990
VAMP4
Vesicle-associated membrane protein 4 (134 aa)
     
  0.977
NSF
Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity); Belongs to the AAA ATPase family (816 aa)
     
 
  0.935
VAMP1
Vesicle-associated membrane protein 1 (synaptobrevin 1) (118 aa)
     
  0.930
SLC6A3
Transporter; Solute carrier family 6 (neurotransmitter transporter), member 3; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family (576 aa)
     
  0.911
SNAP29
Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions (258 aa)
     
  0.904
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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