| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL | EGF | ENSPPYP00000004540 | ENSPPYP00000016752 | Cbl proto-oncogene. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.550 |
| CBL | EGFR | ENSPPYP00000004540 | ENSPPYP00000019671 | Cbl proto-oncogene. | Receptor protein-tyrosine kinase. | 0.999 |
| CBL | GRB2 | ENSPPYP00000004540 | ENSPPYP00000009686 | Cbl proto-oncogene. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.996 |
| CBL | HBEGF | ENSPPYP00000004540 | ENSPPYP00000017724 | Cbl proto-oncogene. | Heparin binding EGF like growth factor. | 0.537 |
| CBL | PIK3CA | ENSPPYP00000004540 | ENSPPYP00000023529 | Cbl proto-oncogene. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.967 |
| CBL | PIK3R1 | ENSPPYP00000004540 | ENSPPYP00000017341 | Cbl proto-oncogene. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.986 |
| CBL | PTPN11 | ENSPPYP00000004540 | ENSPPYP00000005677 | Cbl proto-oncogene. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.915 |
| CBL | SRC | ENSPPYP00000004540 | ENSPPYP00000012270 | Cbl proto-oncogene. | Tyrosine-protein kinase. | 0.972 |
| CBL | STAT3 | ENSPPYP00000004540 | ENSPPYP00000009437 | Cbl proto-oncogene. | Signal transducer and activator of transcription. | 0.629 |
| CBL | TGFA | ENSPPYP00000004540 | ENSPPYP00000013742 | Cbl proto-oncogene. | TGFA isoform 5. | 0.451 |
| EGF | CBL | ENSPPYP00000016752 | ENSPPYP00000004540 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Cbl proto-oncogene. | 0.550 |
| EGF | EGFR | ENSPPYP00000016752 | ENSPPYP00000019671 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Receptor protein-tyrosine kinase. | 0.999 |
| EGF | GRB2 | ENSPPYP00000016752 | ENSPPYP00000009686 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.690 |
| EGF | HBEGF | ENSPPYP00000016752 | ENSPPYP00000017724 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Heparin binding EGF like growth factor. | 0.758 |
| EGF | PIK3CA | ENSPPYP00000016752 | ENSPPYP00000023529 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.829 |
| EGF | PIK3R1 | ENSPPYP00000016752 | ENSPPYP00000017341 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.654 |
| EGF | PTPN11 | ENSPPYP00000016752 | ENSPPYP00000005677 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.675 |
| EGF | SRC | ENSPPYP00000016752 | ENSPPYP00000012270 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Tyrosine-protein kinase. | 0.717 |
| EGF | STAT3 | ENSPPYP00000016752 | ENSPPYP00000009437 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Signal transducer and activator of transcription. | 0.572 |
| EGF | TGFA | ENSPPYP00000016752 | ENSPPYP00000013742 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | TGFA isoform 5. | 0.966 |
