TAX1BP1 protein (Pongo abelii) - STRING interaction network

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TAX1BP1

Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). (771 aa)

Predicted Functional Partners:

TNFAIP3

0.994

MYO6

0.911

AZI2

0.900

UBC

0.892

RNF11

0.862

TRAF6

0.859

CNTN2

0.820

BIRC2

0.798

TBK1

0.797

LGALS8

0.769

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZI2	TAX1BP1	ENSPPYP00000015723	ENSPPYP00000019830	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	0.900
AZI2	TBK1	ENSPPYP00000015723	ENSPPYP00000005386	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	TANK binding kinase 1.	0.999
BIRC2	TAX1BP1	ENSPPYP00000004356	ENSPPYP00000019830	Baculoviral IAP repeat containing 2.	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	0.798
BIRC2	TBK1	ENSPPYP00000004356	ENSPPYP00000005386	Baculoviral IAP repeat containing 2.	TANK binding kinase 1.	0.727
BIRC2	TNFAIP3	ENSPPYP00000004356	ENSPPYP00000019084	Baculoviral IAP repeat containing 2.	TNFAIP3 isoform 1.	0.846
BIRC2	TRAF6	ENSPPYP00000004356	ENSPPYP00000003845	Baculoviral IAP repeat containing 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.931
BIRC2	UBC	ENSPPYP00000004356	ENSPPYP00000005811	Baculoviral IAP repeat containing 2.	UBC isoform 2.	0.951
CNTN2	TAX1BP1	ENSPPYP00000000340	ENSPPYP00000019830	CNTN2 isoform 10.	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	0.820
CNTN2	TBK1	ENSPPYP00000000340	ENSPPYP00000005386	CNTN2 isoform 10.	TANK binding kinase 1.	0.408
LGALS8	TAX1BP1	ENSPPYP00000000086	ENSPPYP00000019830	Galectin.	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	0.769
MYO6	TAX1BP1	ENSPPYP00000018788	ENSPPYP00000019830	MYO6 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	0.911
MYO6	UBC	ENSPPYP00000018788	ENSPPYP00000005811	MYO6 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	UBC isoform 2.	0.895
RNF11	TAX1BP1	ENSPPYP00000001585	ENSPPYP00000019830	Ring finger protein 11.	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	0.862
RNF11	TNFAIP3	ENSPPYP00000001585	ENSPPYP00000019084	Ring finger protein 11.	TNFAIP3 isoform 1.	0.813
TAX1BP1	AZI2	ENSPPYP00000019830	ENSPPYP00000015723	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	0.900
TAX1BP1	BIRC2	ENSPPYP00000019830	ENSPPYP00000004356	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	Baculoviral IAP repeat containing 2.	0.798
TAX1BP1	CNTN2	ENSPPYP00000019830	ENSPPYP00000000340	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	CNTN2 isoform 10.	0.820
TAX1BP1	LGALS8	ENSPPYP00000019830	ENSPPYP00000000086	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	Galectin.	0.769
TAX1BP1	MYO6	ENSPPYP00000019830	ENSPPYP00000018788	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	MYO6 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.911
TAX1BP1	RNF11	ENSPPYP00000019830	ENSPPYP00000001585	Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).	Ring finger protein 11.	0.862

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